Spectrophotometric investigation of the binding of vitamin E to water-containing reversed micelles
The distribution constants of vitamin E partitioned between apolar organic phase and water-containing reversed micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB), soybean phosphatidylcholine (lecithin) and tetraethylene glycol monododecyl ether (C 12...
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| Veröffentlicht in: | International journal of pharmaceutics 2002-03, Vol.234 (1), p.249-255 |
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| container_title | International journal of pharmaceutics |
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| creator | Avellone, G Bongiorno, D Ceraulo, L Ferrugia, M Turco Liveri, V |
| description | The distribution constants of vitamin E partitioned between apolar organic phase and water-containing reversed micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB), soybean phosphatidylcholine (lecithin) and tetraethylene glycol monododecyl ether (C
12E
4) have been evaluated by a spectrophotometric method. The results suggest that in the presence of domains from apolar organic solvent to surfactant and to water, vitamin E is partitioned between the micellar palisade layer and the organic solvent and also that its binding strength to reversed micelles depends mainly by specific interactions between the head group of vitamin E and that of the surfactant. Moreover, in addition to the advantageous interactions between vitamin E and water, the dependence of the distribution constants upon the molar ratio
R (
R=[water]/[surfactant]) indicates a competition between water and vitamin E for the binding sites at the water/surfactant interface. The biological implications of the preferential location and confinement of vitamin E in water-containing reversed micelles are discussed. |
| doi_str_mv | 10.1016/S0378-5173(01)00970-X |
| format | Article |
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12E
4) have been evaluated by a spectrophotometric method. The results suggest that in the presence of domains from apolar organic solvent to surfactant and to water, vitamin E is partitioned between the micellar palisade layer and the organic solvent and also that its binding strength to reversed micelles depends mainly by specific interactions between the head group of vitamin E and that of the surfactant. Moreover, in addition to the advantageous interactions between vitamin E and water, the dependence of the distribution constants upon the molar ratio
R (
R=[water]/[surfactant]) indicates a competition between water and vitamin E for the binding sites at the water/surfactant interface. The biological implications of the preferential location and confinement of vitamin E in water-containing reversed micelles are discussed.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(01)00970-X</identifier><identifier>PMID: 11839455</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Algorithms ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Dioctyl Sulfosuccinic Acid ; General pharmacology ; Medical sciences ; Membrane models ; Micelles ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Phosphatidylcholines ; Quaternary Ammonium Compounds ; Reversed micelles ; Spectrophotometry, Ultraviolet ; Surface-Active Agents ; UV–vis spectroscopy ; Vitamin E ; Vitamin E - chemistry ; Water</subject><ispartof>International journal of pharmaceutics, 2002-03, Vol.234 (1), p.249-255</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-530fa93c4fa3aa89609254129e08c234f32519cddd89fb1ab0a25acc72033e673</citedby><cites>FETCH-LOGICAL-c391t-530fa93c4fa3aa89609254129e08c234f32519cddd89fb1ab0a25acc72033e673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-5173(01)00970-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13481866$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11839455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avellone, G</creatorcontrib><creatorcontrib>Bongiorno, D</creatorcontrib><creatorcontrib>Ceraulo, L</creatorcontrib><creatorcontrib>Ferrugia, M</creatorcontrib><creatorcontrib>Turco Liveri, V</creatorcontrib><title>Spectrophotometric investigation of the binding of vitamin E to water-containing reversed micelles</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The distribution constants of vitamin E partitioned between apolar organic phase and water-containing reversed micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB), soybean phosphatidylcholine (lecithin) and tetraethylene glycol monododecyl ether (C
12E
4) have been evaluated by a spectrophotometric method. The results suggest that in the presence of domains from apolar organic solvent to surfactant and to water, vitamin E is partitioned between the micellar palisade layer and the organic solvent and also that its binding strength to reversed micelles depends mainly by specific interactions between the head group of vitamin E and that of the surfactant. Moreover, in addition to the advantageous interactions between vitamin E and water, the dependence of the distribution constants upon the molar ratio
R (
R=[water]/[surfactant]) indicates a competition between water and vitamin E for the binding sites at the water/surfactant interface. The biological implications of the preferential location and confinement of vitamin E in water-containing reversed micelles are discussed.</description><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Dioctyl Sulfosuccinic Acid</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Membrane models</subject><subject>Micelles</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylcholines</subject><subject>Quaternary Ammonium Compounds</subject><subject>Reversed micelles</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Surface-Active Agents</subject><subject>UV–vis spectroscopy</subject><subject>Vitamin E</subject><subject>Vitamin E - chemistry</subject><subject>Water</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQQC1ERbeFnwDKBVQOgXEcx_apQlWBSpU4FKTerIkzaY029mJ7F_XfN-mu6JHTaKQ3X28Ye8vhEwfefb4BoXQtuRJnwD8CGAX17Qu24lqJWrSqe8lW_5BjdpLzbwDoGi5esWPOtTCtlCvW32zIlRQ397HEiUryrvJhR7n4Oyw-hiqOVbmnqvdh8OFuSXe-4ORDdVmVWP3FQql2MRT0YQES7ShlGqrJO1qvKb9mRyOuM705xFP26-vlz4vv9fWPb1cXX65rJwwvtRQwohGuHVEgatOBaWTLG0OgXSPaUTSSGzcMgzZjz7EHbCQ6pxoQgjolTtmHfd9Nin-28wV28nlZAQPFbbaKtxK0amdQ7kGXYs6JRrtJfsL0YDnYRa59kmsXcxa4fZJrb-e6d4cB236i4bnqYHMG3h8AzA7XY8LgfH7mRKu57rqZO99zNOvYeUo2O0_B0eDT_A07RP-fVR4BDTaX3w</recordid><startdate>20020302</startdate><enddate>20020302</enddate><creator>Avellone, G</creator><creator>Bongiorno, D</creator><creator>Ceraulo, L</creator><creator>Ferrugia, M</creator><creator>Turco Liveri, V</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020302</creationdate><title>Spectrophotometric investigation of the binding of vitamin E to water-containing reversed micelles</title><author>Avellone, G ; Bongiorno, D ; Ceraulo, L ; Ferrugia, M ; Turco Liveri, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-530fa93c4fa3aa89609254129e08c234f32519cddd89fb1ab0a25acc72033e673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Dioctyl Sulfosuccinic Acid</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Membrane models</topic><topic>Micelles</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylcholines</topic><topic>Quaternary Ammonium Compounds</topic><topic>Reversed micelles</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Surface-Active Agents</topic><topic>UV–vis spectroscopy</topic><topic>Vitamin E</topic><topic>Vitamin E - chemistry</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avellone, G</creatorcontrib><creatorcontrib>Bongiorno, D</creatorcontrib><creatorcontrib>Ceraulo, L</creatorcontrib><creatorcontrib>Ferrugia, M</creatorcontrib><creatorcontrib>Turco Liveri, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avellone, G</au><au>Bongiorno, D</au><au>Ceraulo, L</au><au>Ferrugia, M</au><au>Turco Liveri, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrophotometric investigation of the binding of vitamin E to water-containing reversed micelles</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2002-03-02</date><risdate>2002</risdate><volume>234</volume><issue>1</issue><spage>249</spage><epage>255</epage><pages>249-255</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The distribution constants of vitamin E partitioned between apolar organic phase and water-containing reversed micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT), didodecyldimethylammonium bromide (DDAB), soybean phosphatidylcholine (lecithin) and tetraethylene glycol monododecyl ether (C
12E
4) have been evaluated by a spectrophotometric method. The results suggest that in the presence of domains from apolar organic solvent to surfactant and to water, vitamin E is partitioned between the micellar palisade layer and the organic solvent and also that its binding strength to reversed micelles depends mainly by specific interactions between the head group of vitamin E and that of the surfactant. Moreover, in addition to the advantageous interactions between vitamin E and water, the dependence of the distribution constants upon the molar ratio
R (
R=[water]/[surfactant]) indicates a competition between water and vitamin E for the binding sites at the water/surfactant interface. The biological implications of the preferential location and confinement of vitamin E in water-containing reversed micelles are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11839455</pmid><doi>10.1016/S0378-5173(01)00970-X</doi><tpages>7</tpages></addata></record> |
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| subjects | Algorithms Biological and medical sciences Chemical Phenomena Chemistry, Physical Dioctyl Sulfosuccinic Acid General pharmacology Medical sciences Membrane models Micelles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylcholines Quaternary Ammonium Compounds Reversed micelles Spectrophotometry, Ultraviolet Surface-Active Agents UV–vis spectroscopy Vitamin E Vitamin E - chemistry Water |
| title | Spectrophotometric investigation of the binding of vitamin E to water-containing reversed micelles |
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