Elevation of serum thrombopoietin precedes thrombocytosis in acute infections
To clarify the mechanisms underlying thrombocytosis secondary to infections, we longitudinally studied serum levels of thrombopoietin (TPO) and interleukin (IL)‐6 in 15 infants and young children with prominent thrombocytosis (platelets > 700 × 109/l) following acute infections and 116 age‐matche...
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| Veröffentlicht in: | British journal of haematology 2002-03, Vol.116 (3), p.612-618 |
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| container_title | British journal of haematology |
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| creator | Ishiguro, Akira Suzuki, Yoko Mito, Mari Shimbo, Toshikazu Matsubara, Kousaku Kato, Takashi Miyazaki, Hiroshi |
| description | To clarify the mechanisms underlying thrombocytosis secondary to infections, we longitudinally studied serum levels of thrombopoietin (TPO) and interleukin (IL)‐6 in 15 infants and young children with prominent thrombocytosis (platelets > 700 × 109/l) following acute infections and 116 age‐matched controls using an enzyme‐linked immunosorbent assay. The subjects included nine patients with bacterial infections, three with viral infections and three with non‐determined pathogens. TPO values in the controls were 2·24 ± 0·87 fmol/ml (mean ± SD) with a 95% reference interval of 0·85–4·47 fmol/ml. In the first week of infection, platelet counts were normal, but TPO values increased (∼10·73 fmol/ml). TPO levels peaked on day 4 ± 2 at 6·44 ± 2·37 fmol/ml and then fell gradually. When platelet counts peaked in the second and third weeks, TPO levels were similar to the controls. IL‐6 levels in the first week rose and dropped more rapidly than TPO. Serum TPO values were significantly correlated with C‐reactive protein levels (r = 0·688, P |
| doi_str_mv | 10.1046/j.0007-1048.2001.03304.x |
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The subjects included nine patients with bacterial infections, three with viral infections and three with non‐determined pathogens. TPO values in the controls were 2·24 ± 0·87 fmol/ml (mean ± SD) with a 95% reference interval of 0·85–4·47 fmol/ml. In the first week of infection, platelet counts were normal, but TPO values increased (∼10·73 fmol/ml). TPO levels peaked on day 4 ± 2 at 6·44 ± 2·37 fmol/ml and then fell gradually. When platelet counts peaked in the second and third weeks, TPO levels were similar to the controls. IL‐6 levels in the first week rose and dropped more rapidly than TPO. Serum TPO values were significantly correlated with C‐reactive protein levels (r = 0·688, P < 0·001) and IL‐6 levels (r = 0·481, P = 0·027). These results suggest that TPO contributes to thrombocytosis following infections in conjunction with IL‐6, arguing for additional regulatory mechanisms of blood TPO levels.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.0007-1048.2001.03304.x</identifier><identifier>PMID: 11849220</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Acute Disease ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Child, Preschool ; children ; Female ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Infant ; infection ; Infection - blood ; Infection - complications ; Interleukin-6 - blood ; Longitudinal Studies ; Male ; Medical sciences ; platelet ; Platelet Count ; Platelet diseases and coagulopathies ; Reference Values ; thrombocytosis ; Thrombocytosis - blood ; Thrombocytosis - microbiology ; thrombopoietin ; Thrombopoietin - blood</subject><ispartof>British journal of haematology, 2002-03, Vol.116 (3), p.612-618</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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The subjects included nine patients with bacterial infections, three with viral infections and three with non‐determined pathogens. TPO values in the controls were 2·24 ± 0·87 fmol/ml (mean ± SD) with a 95% reference interval of 0·85–4·47 fmol/ml. In the first week of infection, platelet counts were normal, but TPO values increased (∼10·73 fmol/ml). TPO levels peaked on day 4 ± 2 at 6·44 ± 2·37 fmol/ml and then fell gradually. When platelet counts peaked in the second and third weeks, TPO levels were similar to the controls. IL‐6 levels in the first week rose and dropped more rapidly than TPO. Serum TPO values were significantly correlated with C‐reactive protein levels (r = 0·688, P < 0·001) and IL‐6 levels (r = 0·481, P = 0·027). These results suggest that TPO contributes to thrombocytosis following infections in conjunction with IL‐6, arguing for additional regulatory mechanisms of blood TPO levels.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - metabolism</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infant</subject><subject>infection</subject><subject>Infection - blood</subject><subject>Infection - complications</subject><subject>Interleukin-6 - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>platelet</subject><subject>Platelet Count</subject><subject>Platelet diseases and coagulopathies</subject><subject>Reference Values</subject><subject>thrombocytosis</subject><subject>Thrombocytosis - blood</subject><subject>Thrombocytosis - microbiology</subject><subject>thrombopoietin</subject><subject>Thrombopoietin - blood</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFP3DAQhS1UBAvtX0BRpfaWdMZ2NvaBQ0FQWoG40LPldSYiqyRe7ATYf1-nuy1STz1YfrK_efP0GMsQCgS5_LIuAKDKk1YFB8AChABZvB6wBYplmXOU-I4t_kLH7CTGdQIFlHjEjhGV1JzDgt1ddfRsx9YPmW-ySGHqs_Ex-H7lN76lsR2yTSBHNcU_7247-tjGLH1ZN42URENutojv2WFju0gf9vcp-3l99XB5k9_ef_t--fU2d1IpmXOlETUHB1oDWrcEqStZWrKuXqlKUDo1SQW65kgCV4QcSMzDDZWlEKfs8853E_zTRHE0fRsddZ0dyE_RVChLqDhP4Md_wLWfwpCyGdQq7eW8SpDaQS74GAM1ZhPa3oatQTBz32Zt5ipnrczct_ndt3lNo2d7_2nVU_02uC84AZ_2gI3Odk2wg2vjGyeqqtRqznC-417ajrb_HcBc_LiZlfgFsJGaWQ</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Ishiguro, Akira</creator><creator>Suzuki, Yoko</creator><creator>Mito, Mari</creator><creator>Shimbo, Toshikazu</creator><creator>Matsubara, Kousaku</creator><creator>Kato, Takashi</creator><creator>Miyazaki, Hiroshi</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Elevation of serum thrombopoietin precedes thrombocytosis in acute infections</title><author>Ishiguro, Akira ; Suzuki, Yoko ; Mito, Mari ; Shimbo, Toshikazu ; Matsubara, Kousaku ; Kato, Takashi ; Miyazaki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4884-28911920c09901ac6049745aeacdb873e873de4809d21e31be120e3c488fe5533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - metabolism</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infant</topic><topic>infection</topic><topic>Infection - blood</topic><topic>Infection - complications</topic><topic>Interleukin-6 - blood</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>platelet</topic><topic>Platelet Count</topic><topic>Platelet diseases and coagulopathies</topic><topic>Reference Values</topic><topic>thrombocytosis</topic><topic>Thrombocytosis - blood</topic><topic>Thrombocytosis - microbiology</topic><topic>thrombopoietin</topic><topic>Thrombopoietin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishiguro, Akira</creatorcontrib><creatorcontrib>Suzuki, Yoko</creatorcontrib><creatorcontrib>Mito, Mari</creatorcontrib><creatorcontrib>Shimbo, Toshikazu</creatorcontrib><creatorcontrib>Matsubara, Kousaku</creatorcontrib><creatorcontrib>Kato, Takashi</creatorcontrib><creatorcontrib>Miyazaki, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishiguro, Akira</au><au>Suzuki, Yoko</au><au>Mito, Mari</au><au>Shimbo, Toshikazu</au><au>Matsubara, Kousaku</au><au>Kato, Takashi</au><au>Miyazaki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevation of serum thrombopoietin precedes thrombocytosis in acute infections</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>116</volume><issue>3</issue><spage>612</spage><epage>618</epage><pages>612-618</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>To clarify the mechanisms underlying thrombocytosis secondary to infections, we longitudinally studied serum levels of thrombopoietin (TPO) and interleukin (IL)‐6 in 15 infants and young children with prominent thrombocytosis (platelets > 700 × 109/l) following acute infections and 116 age‐matched controls using an enzyme‐linked immunosorbent assay. The subjects included nine patients with bacterial infections, three with viral infections and three with non‐determined pathogens. TPO values in the controls were 2·24 ± 0·87 fmol/ml (mean ± SD) with a 95% reference interval of 0·85–4·47 fmol/ml. In the first week of infection, platelet counts were normal, but TPO values increased (∼10·73 fmol/ml). TPO levels peaked on day 4 ± 2 at 6·44 ± 2·37 fmol/ml and then fell gradually. When platelet counts peaked in the second and third weeks, TPO levels were similar to the controls. IL‐6 levels in the first week rose and dropped more rapidly than TPO. Serum TPO values were significantly correlated with C‐reactive protein levels (r = 0·688, P < 0·001) and IL‐6 levels (r = 0·481, P = 0·027). These results suggest that TPO contributes to thrombocytosis following infections in conjunction with IL‐6, arguing for additional regulatory mechanisms of blood TPO levels.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>11849220</pmid><doi>10.1046/j.0007-1048.2001.03304.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute Disease Biological and medical sciences C-Reactive Protein - metabolism Child, Preschool children Female Hematologic and hematopoietic diseases Hematology Humans Infant infection Infection - blood Infection - complications Interleukin-6 - blood Longitudinal Studies Male Medical sciences platelet Platelet Count Platelet diseases and coagulopathies Reference Values thrombocytosis Thrombocytosis - blood Thrombocytosis - microbiology thrombopoietin Thrombopoietin - blood |
| title | Elevation of serum thrombopoietin precedes thrombocytosis in acute infections |
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