Transfection of airway epithelium by stable PEGylated poly-l-lysine DNA nanoparticles in vivo

DNA can be compacted using polyethylene glycol-substituted poly-l-lysine into discrete unimolecular (with respect to DNA) nanoparticles with minor diameter

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular therapy 2003-12, Vol.8 (6), p.936-947
Hauptverfasser:	Ziady, Assem-Galal, Gedeon, Christopher R, Miller, Timothy, Quan, William, Payne, Jennifer M, Hyatt, Susannah L, Fink, Tamara L, Muhammad, Osman, Oette, Sharon, Kowalczyk, Tomasz, Pasumarthy, Murali K, Moen, Robert C, Cooper, Mark J, Davis, Pamela B
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Bronchi - metabolism DNA - administration & dosage DNA - metabolism Epithelium - metabolism Experiments Gene expression Gene therapy Genes, Reporter Immunohistochemistry Intubation, Intratracheal Lungs Mice Nanoparticles NMR Nuclear magnetic resonance Pediatrics Plasmids Polyethylene glycol Polyethylene Glycols - metabolism Polylysine - metabolism Proteins Transfection
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Beschreibung
Zusammenfassung:	DNA can be compacted using polyethylene glycol-substituted poly-l-lysine into discrete unimolecular (with respect to DNA) nanoparticles with minor diameter
ISSN:	1525-0016 1525-0024
DOI:	10.1016/j.ymthe.2003.07.007