Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

The klotho gene encodes a novel type I membrane protein of β-glycosidase family and is expressed principally in distal tubule cells of the kidney and choroid plexus in the brain. These mutants displayed abnormal calcium and phosphorus homeostasis together with increased serum 1,25-(OH)2D. In kl−/− m...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2003-12, Vol.17 (12), p.2393-2403
Hauptverfasser:	Tsujikawa, Hiroshi, Kurotaki, Yoko, Fujimori, Toshihiko, Fukuda, Kazuhiko, Nabeshima, Yo-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics Aging, Premature - genetics Animals Body Weight Calcitriol - blood Diet Disease Models, Animal Gene Expression Regulation - genetics Glucuronidase Humans Kidney - metabolism Klotho gene Membrane Proteins - deficiency Membrane Proteins - genetics Mice Mice, Knockout Reference Values RNA - genetics RNA - isolation & purification Vitamin D - physiology Vitamin D Deficiency - blood
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