Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation

The zinc finger transcription factor GLI1, which mediates Sonic hedgehog signaling during development, is expressed in several human cancers, including basal cell carcinoma, medulloblastoma, and sarcomas. We identified 147 genes whose levels of expression were significantly altered in RNA obtained f...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (7), p.5548-5555
Hauptverfasser:	Yoon, Joon Won, Kita, Yasuhiro, Frank, Daniel J, Majewski, Rebecca R, Konicek, Beth A, Nobrega, Marcelo A, Jacob, Howard, Walterhouse, David, Iannaccone, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Apoptosis Base Sequence Biotinylation Blotting, Northern Cell Adhesion Cell Line, Transformed Cyclin D2 Cyclins - biosynthesis Cytoskeletal Proteins - biosynthesis Desmoplakins DNA, Complementary - metabolism Down-Regulation gamma Catenin GLI1 protein Ha-ras gene Humans In Situ Hybridization Insulin-Like Growth Factor Binding Protein 6 - biosynthesis Models, Biological Molecular Sequence Data Oligonucleotide Array Sequence Analysis Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Osteopontin Phenotype plakoglobin Protein Binding Protein Structure, Tertiary ras Proteins - biosynthesis Rats Recombinant Fusion Proteins - metabolism Rhabdomyosarcoma - metabolism RNA - metabolism RNA, Messenger - metabolism Sialoglycoproteins - biosynthesis Signal Transduction Trans-Activators Transcription Factors - biosynthesis Transcription Factors - genetics Tumor Cells, Cultured Up-Regulation Zinc Finger Protein GLI1
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