Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

The enzyme sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that acts extracellularly on G protein-coupled receptors of the S1P(1)/EDG-1 subfamily. Although S1P is formed in the cytosol of various cells, S1P release is not understood and is controve...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (8), p.6667-6675
Hauptverfasser:	Ancellin, Nicolas, Colmont, Chantal, Su, Joseph, Li, Qin, Mittereder, Nanette, Chae, Sung-Suk, Stefansson, Steingrimur, Liau, Gene, Hla, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cell Line Culture Media, Conditioned Cytosol - metabolism Endothelium, Vascular - metabolism Female Gene Expression Regulation, Enzymologic Gene Silencing Homeodomain Proteins - metabolism Humans Immediate-Early Proteins - metabolism Kidney Kinetics Lysophospholipids Neovascularization, Physiologic Oocytes - physiology Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Transport Receptors, Cell Surface Receptors, G-Protein-Coupled Receptors, Lysophospholipid Repressor Proteins - metabolism RNA, Small Interfering RNA, Untranslated - genetics Sphingosine - analogs & derivatives Sphingosine - metabolism Transfection Xenopus Xenopus Proteins Zinc Finger E-box Binding Homeobox 2
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