Calix[6]arene-Based Cuprous “Funnel Complexes”: A Mimic for the Substrate Access Channel to Metalloenzyme Active Sites

Two calixarene-based model systems (a and b) for monocopper enzymes are compared. Both present a tris(pyridine) coordination site for Cu that mimics the imidazole-rich neutral binding site in enzymes. Upon reaction with 1 equiv of copper(I), the tridentate ligands gave rise to ill-defined unsymmetri...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-02, Vol.124 (7), p.1334-1340
Hauptverfasser:	Rondelez, Yannick, Duprat, Arthur, Reinaud, Olivia
Format:	Artikel
Sprache:	eng
Schlagworte:	Calixarenes Chemistry Coordination compounds Copper - chemistry Copper - metabolism Enzymes - chemistry Enzymes - metabolism Exact sciences and technology Inorganic chemistry and origins of life Kinetics Ligands Macromolecular Substances Metalloproteins - chemistry Metalloproteins - metabolism Molecular Mimicry Nuclear Magnetic Resonance, Biomolecular Preparations and properties Protein Folding Thermodynamics
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