The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers

Objective:The purpose of this study was to evaluate the rate of absorption and relative bioavailability of caffeine from a Stay Alert® chewing gum and capsule formulation. Methods: This was a double blind, parallel, randomized, seven treatment study. The treatment groups were: 50, 100, and 200 mg gu...

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Veröffentlicht in:	International journal of pharmaceutics 2002-03, Vol.234 (1), p.159-167
Hauptverfasser:	Kamimori, Gary H, Karyekar, Chetan S, Otterstetter, Ronald, Cox, Donna S, Balkin, Thomas J, Belenky, Gregory L, Eddington, Natalie D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Area Under Curve Biological and medical sciences Biological Availability Caffeine Caffeine - administration & dosage Caffeine - chemistry Caffeine - pharmacokinetics Capsules Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - chemistry Central Nervous System Stimulants - pharmacokinetics Chewing Gum Chromatography, High Pressure Liquid Double-Blind Method General pharmacology Humans Intestinal Absorption Male Medical sciences Neuropharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rate of absorption Relative bioavailability Spectrophotometry, Ultraviolet
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