Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities
Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with...
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| Veröffentlicht in: | British journal of haematology 2002-01, Vol.116 (1), p.113-121 |
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| creator | Wilson, Kathleen S. McKenna, Robert W. Kroft, Steven H. Dawson, D. Brian Ansari, Qasim Schneider, Nancy R. |
| description | Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate data obtained from the cell line studies that trisomy 7, trisomy 12 and aberrations in the proximal long arm of chromosome 1 (1q) are recurring cytogenetic aberrations in PEL and also identify breakpoints at 3q23, 7p22, 7q22, 10q24, 12q24, 13q22, 14q24, 14q32, 15p11.2 and Xq22 as well as +8, +15, +19, +X and –Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL. |
| doi_str_mv | 10.1046/j.1365-2141.2002.03193.x |
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The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2002.03193.x</identifier><identifier>PMID: 11841403</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Adult ; Antigens, CD - analysis ; Ascitic Fluid - immunology ; Biological and medical sciences ; Biomarkers - analysis ; chromosome ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 7 ; cytogenetics ; Genotype ; Hematologic and hematopoietic diseases ; Hematology ; Herpesvirus 8, Human ; human herpesvirus type 8 ; Humans ; Immunophenotyping ; karyotype ; Karyotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, AIDS-Related - genetics ; Lymphoma, AIDS-Related - immunology ; Lymphoma, AIDS-Related - virology ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - immunology ; Lymphoma, B-Cell - virology ; Male ; Medical sciences ; Middle Aged ; primary effusion lymphoma ; Trisomy</subject><ispartof>British journal of haematology, 2002-01, Vol.116 (1), p.113-121</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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Brian</creatorcontrib><creatorcontrib>Ansari, Qasim</creatorcontrib><creatorcontrib>Schneider, Nancy R.</creatorcontrib><title>Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate data obtained from the cell line studies that trisomy 7, trisomy 12 and aberrations in the proximal long arm of chromosome 1 (1q) are recurring cytogenetic aberrations in PEL and also identify breakpoints at 3q23, 7p22, 7q22, 10q24, 12q24, 13q22, 14q24, 14q32, 15p11.2 and Xq22 as well as +8, +15, +19, +X and –Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL.</description><subject>Adult</subject><subject>Antigens, CD - analysis</subject><subject>Ascitic Fluid - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>chromosome</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Chromosomes, Human, Pair 7</subject><subject>cytogenetics</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Herpesvirus 8, Human</subject><subject>human herpesvirus type 8</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>karyotype</subject><subject>Karyotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, AIDS-Related - genetics</subject><subject>Lymphoma, AIDS-Related - immunology</subject><subject>Lymphoma, AIDS-Related - virology</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - immunology</subject><subject>Lymphoma, B-Cell - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>primary effusion lymphoma</subject><subject>Trisomy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EokvhFVCEBLeEGdtxnAMHWgGlqkRV9W45zoR6lcSLnYjdtydhV1Ti1NNY4-8f_foYyxAKBKk-bgsUqsw5Siw4AC9AYC2K_TO2-ffxnG0AoMqXgD5jr1LaAqCAEl-yM0QtUYLYsLvb6AcbDxl13Zx8GLP-MOwewmBTRvsH3_gpc2HY9bTP7NhmkdwcI43L9jCFnzTS5F1mmzHEwfZ-8pResxed7RO9Oc1zdv_1y_3lVX7z49v3y883uSuFFnlTOwetqnTNwXEuFZa1Eo3juulKqoRooS0555Z3wuq2ElbxTiMJwspaEOfsw_HsLoZfM6XJDD456ns7UpiTqVDKSoJawHf_gdswx3GpZrDWJSrg5QLpI-RiSClSZ3ZHMQbBrM7N1qxqzarWrM7NX-dmv0Tfnu7PzUDtY_AkeQHenwCbnO27aEfn0yMnlKikWot-OnK_fU-HJxcwF9dX60v8AZsInJM</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Wilson, Kathleen S.</creator><creator>McKenna, Robert W.</creator><creator>Kroft, Steven H.</creator><creator>Dawson, D. Brian</creator><creator>Ansari, Qasim</creator><creator>Schneider, Nancy R.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities</title><author>Wilson, Kathleen S. ; McKenna, Robert W. ; Kroft, Steven H. ; Dawson, D. Brian ; Ansari, Qasim ; Schneider, Nancy R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5383-b9cc0d678920c224615963bc28bf5e733d0d5222a2f3a8d73a62f81e3e17aa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antigens, CD - analysis</topic><topic>Ascitic Fluid - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>chromosome</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Chromosomes, Human, Pair 7</topic><topic>cytogenetics</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Herpesvirus 8, Human</topic><topic>human herpesvirus type 8</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>karyotype</topic><topic>Karyotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, AIDS-Related - genetics</topic><topic>Lymphoma, AIDS-Related - immunology</topic><topic>Lymphoma, AIDS-Related - virology</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, B-Cell - immunology</topic><topic>Lymphoma, B-Cell - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>primary effusion lymphoma</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, Kathleen S.</creatorcontrib><creatorcontrib>McKenna, Robert W.</creatorcontrib><creatorcontrib>Kroft, Steven H.</creatorcontrib><creatorcontrib>Dawson, D. Brian</creatorcontrib><creatorcontrib>Ansari, Qasim</creatorcontrib><creatorcontrib>Schneider, Nancy R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, Kathleen S.</au><au>McKenna, Robert W.</au><au>Kroft, Steven H.</au><au>Dawson, D. Brian</au><au>Ansari, Qasim</au><au>Schneider, Nancy R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2002-01</date><risdate>2002</risdate><volume>116</volume><issue>1</issue><spage>113</spage><epage>121</epage><pages>113-121</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate data obtained from the cell line studies that trisomy 7, trisomy 12 and aberrations in the proximal long arm of chromosome 1 (1q) are recurring cytogenetic aberrations in PEL and also identify breakpoints at 3q23, 7p22, 7q22, 10q24, 12q24, 13q22, 14q24, 14q32, 15p11.2 and Xq22 as well as +8, +15, +19, +X and –Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>11841403</pmid><doi>10.1046/j.1365-2141.2002.03193.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antigens, CD - analysis Ascitic Fluid - immunology Biological and medical sciences Biomarkers - analysis chromosome Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 7 cytogenetics Genotype Hematologic and hematopoietic diseases Hematology Herpesvirus 8, Human human herpesvirus type 8 Humans Immunophenotyping karyotype Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, AIDS-Related - genetics Lymphoma, AIDS-Related - immunology Lymphoma, AIDS-Related - virology Lymphoma, B-Cell - genetics Lymphoma, B-Cell - immunology Lymphoma, B-Cell - virology Male Medical sciences Middle Aged primary effusion lymphoma Trisomy |
| title | Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities |
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