The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7

Within minutes after infecting Escherichia coli, bacteriophage T7 synthesizes many copies of its genomic DNA. The lynchpin of the T7 replication system is a bifunctional primase-helicase that unwinds duplex DNA at the replication fork while initiating the synthesis of Okazaki fragments on the laggin...

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Veröffentlicht in:	Molecular Cell 2003-11, Vol.12 (5), p.1113-1123
Hauptverfasser:	Toth, Eric A., Li, Ying, Sawaya, Michael R., Cheng, Yifan, Ellenberger, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T7 - enzymology BACTERIOPHAGES Binding Sites BNL CRYSTAL STRUCTURE Crystallography, X-Ray DNA Primase - chemistry DNA Primase - metabolism MATERIALS MATERIALS SCIENCE Models, Genetic Models, Molecular Molecular Sequence Data NATIONAL SYNCHROTRON LIGHT SOURCE Protein Structure, Quaternary Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - metabolism
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