Functional Expression of Human Mitochondrial CYP11B2 in Fission Yeast and Identification of a New Internal Electron Transfer Protein, etp1

Mitochondrial cytochrome P450 enzymes play a crucial role in the steroid biosynthesis in human adrenals, catalyzing regio- and stereospecific hydroxylations. In search of a new model system for the study of these enzymes, we expressed the human CYP11B2 (aldosterone synthase, P450aldo) in fission yea...

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Veröffentlicht in:	Biochemistry (Easton) 2002-02, Vol.41 (7), p.2311-2321
Hauptverfasser:	Bureik, Matthias, Schiffler, Burkhard, Hiraoka, Yasushi, Vogel, Frank, Bernhardt, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenodoxin - chemistry Bacterial Proteins Carrier Proteins - biosynthesis Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cloning, Molecular Cortodoxone - metabolism Cytochrome P-450 CYP11B2 - biosynthesis Cytochrome P-450 CYP11B2 - genetics Cytochrome P-450 CYP11B2 - metabolism Cytochrome P-450 Enzyme System - metabolism Desoxycorticosterone - metabolism Electron Transport - genetics Enzyme Activation - genetics Fungal Proteins - biosynthesis Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Fungal Humans Hydroxylation Membrane Proteins Mitochondria - enzymology Mitochondria - genetics Recombinant Proteins - metabolism Schizosaccharomyces - enzymology Schizosaccharomyces - genetics Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - biosynthesis Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Sequence Analysis, Protein
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