Role of MLK3-mediated Activation of p70 S6 Kinase in Rac1 Transformation

The signaling pathways that mediate the transforming activity of the Rac1 GTPase remain to be determined. In the present study, we used effector domain mutants of the constitutively activated Rac(61L) mutant that display differential transforming activities and differential activation of downstream...

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Veröffentlicht in:	The Journal of biological chemistry 2002-02, Vol.277 (7), p.4770-4777
Hauptverfasser:	Lambert, John M, Karnoub, Antoine E, Graves, Lee M, Campbell, Sharon L, Der, Channing J
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Agar - pharmacology Animals Blotting, Western Cell Line Enzyme Activation Genes, Reporter Genetic Vectors Humans Luciferases - metabolism MAP Kinase Kinase Kinases - metabolism MAP Kinase Kinase Kinases - physiology Mice Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase Kinase Kinase 11 Mitogen-Activated Protein Kinases - metabolism Mutation Plasmids - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary rac1 GTP-Binding Protein - metabolism Ribosomal Protein S6 Kinases - metabolism Signal Transduction Transfection
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