High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition
The human placenta is a neuroendocrine organ that produces several hypothalamic and pituitary hormones that are secreted during pregnancy and parturition into maternal and fetal circulation and amniotic fluid. Human chromogranin A (CgA) is a glycoprotein mainly localized to the adrenal medulla and r...
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| Veröffentlicht in: | Journal of the Society for Gynecologic Investigation 2002-01, Vol.9 (1), p.32-36 |
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| container_title | Journal of the Society for Gynecologic Investigation |
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| creator | FLORIO, Pasquale MEZZESIMI, Alessandra TURCHETTI, Vera SEVERI, Filiberto Maria TICCONI, Carlo FORCONI, Sandro PETRAGLIA, Felice |
| description | The human placenta is a neuroendocrine organ that produces several hypothalamic and pituitary hormones that are secreted during pregnancy and parturition into maternal and fetal circulation and amniotic fluid. Human chromogranin A (CgA) is a glycoprotein mainly localized to the adrenal medulla and released in response to several stressful events. During pregnancy, intrauterine tissues express and synthesize CgA mRNA and peptide and secret it into the biologic fluids of pregnancy, so we investigated whether maternal, umbilical, and amniotic human CgA levels are affected by the stress of parturition.
We measured pregnancy CgA levels in maternal and umbilical cord plasma and in amniotic fluid at term (39-40 weeks), by enzyme-linked immunosorbent assay at elective cesarean (n = 16), after spontaneous vaginal delivery (n = 12), and longitudinally throughout labor and 2 hours postpartum.
CgA levels were highest in umbilical cord blood (P |
| doi_str_mv | 10.1016/s1071-5576(01)00149-6 |
| format | Article |
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We measured pregnancy CgA levels in maternal and umbilical cord plasma and in amniotic fluid at term (39-40 weeks), by enzyme-linked immunosorbent assay at elective cesarean (n = 16), after spontaneous vaginal delivery (n = 12), and longitudinally throughout labor and 2 hours postpartum.
CgA levels were highest in umbilical cord blood (P <.001). Umbilical cord plasma and amniotic fluid CgA levels were significantly higher at spontaneous vaginal delivery than at cesarean (P <.001), and the levels were not changed in maternal plasma according to cervical dilatation and postpartum.
The present findings showed that the stress of parturition increased CgA levels in umbilical cord plasma and amniotic fluid and was probably of fetal origin. Whatever the mode of delivery, CgA levels in infants were much more elevated than in mothers, providing evidence for an unusual and sustained high level of sympathoadrenal stimulation in full-term neonates.</description><identifier>ISSN: 1071-5576</identifier><identifier>EISSN: 1556-7117</identifier><identifier>DOI: 10.1016/s1071-5576(01)00149-6</identifier><identifier>PMID: 11839506</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adult ; Amniotic Fluid - metabolism ; Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Cesarean Section ; Chromogranin A ; Chromogranins - blood ; Chromogranins - metabolism ; Female ; Fetal Blood - metabolism ; Gynecology. Andrology. Obstetrics ; Human bacterial diseases ; Humans ; Infant, Newborn ; Infectious diseases ; Labor, Obstetric - metabolism ; Longitudinal Studies ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta</subject><ispartof>Journal of the Society for Gynecologic Investigation, 2002-01, Vol.9 (1), p.32-36</ispartof><rights>2002 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13506075$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11839506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FLORIO, Pasquale</creatorcontrib><creatorcontrib>MEZZESIMI, Alessandra</creatorcontrib><creatorcontrib>TURCHETTI, Vera</creatorcontrib><creatorcontrib>SEVERI, Filiberto Maria</creatorcontrib><creatorcontrib>TICCONI, Carlo</creatorcontrib><creatorcontrib>FORCONI, Sandro</creatorcontrib><creatorcontrib>PETRAGLIA, Felice</creatorcontrib><title>High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition</title><title>Journal of the Society for Gynecologic Investigation</title><addtitle>J Soc Gynecol Investig</addtitle><description>The human placenta is a neuroendocrine organ that produces several hypothalamic and pituitary hormones that are secreted during pregnancy and parturition into maternal and fetal circulation and amniotic fluid. Human chromogranin A (CgA) is a glycoprotein mainly localized to the adrenal medulla and released in response to several stressful events. During pregnancy, intrauterine tissues express and synthesize CgA mRNA and peptide and secret it into the biologic fluids of pregnancy, so we investigated whether maternal, umbilical, and amniotic human CgA levels are affected by the stress of parturition.
We measured pregnancy CgA levels in maternal and umbilical cord plasma and in amniotic fluid at term (39-40 weeks), by enzyme-linked immunosorbent assay at elective cesarean (n = 16), after spontaneous vaginal delivery (n = 12), and longitudinally throughout labor and 2 hours postpartum.
CgA levels were highest in umbilical cord blood (P <.001). Umbilical cord plasma and amniotic fluid CgA levels were significantly higher at spontaneous vaginal delivery than at cesarean (P <.001), and the levels were not changed in maternal plasma according to cervical dilatation and postpartum.
The present findings showed that the stress of parturition increased CgA levels in umbilical cord plasma and amniotic fluid and was probably of fetal origin. Whatever the mode of delivery, CgA levels in infants were much more elevated than in mothers, providing evidence for an unusual and sustained high level of sympathoadrenal stimulation in full-term neonates.</description><subject>Adult</subject><subject>Amniotic Fluid - metabolism</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Chromogranin A</subject><subject>Chromogranins - blood</subject><subject>Chromogranins - metabolism</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Labor, Obstetric - metabolism</subject><subject>Longitudinal Studies</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><issn>1071-5576</issn><issn>1556-7117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotn78BCUXRQ-rGfO1exRRKwge1KshmyZtJLupya7gvzfVipdMBp53hnkQOgJyAQTEZQYioeJcijMC54QAayqxhabAuagkgNwu_z9kgvZyfi-QLNldNAGoacOJmKK3mV8scbCfNmQcHV6One6xWabYxUXSve_xNS7P2LU-eKMDNjHN8Sro3Gms-znWXe_j4A12YfSlHfBKp2FMfvCxP0A7TodsDzd1H73e3b7czKrHp_uHm-vHylBZD5WYA20bxxm9qq9kKx01UlNgbU24aBviJKtF41oGAgxow8FZw6lwvC43Nozuo9PfuasUP0abB9X5bGwIurdxzEoCY5w1soD8FzQp5pysU6vkO52-FBC1Fque19bU2poioH7EKlFyx5sFY9vZ-X9qY7IAJxtA56LJFXfG53-OFohITr8BsyKAKw</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>FLORIO, Pasquale</creator><creator>MEZZESIMI, Alessandra</creator><creator>TURCHETTI, Vera</creator><creator>SEVERI, Filiberto Maria</creator><creator>TICCONI, Carlo</creator><creator>FORCONI, Sandro</creator><creator>PETRAGLIA, Felice</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition</title><author>FLORIO, Pasquale ; MEZZESIMI, Alessandra ; TURCHETTI, Vera ; SEVERI, Filiberto Maria ; TICCONI, Carlo ; FORCONI, Sandro ; PETRAGLIA, Felice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-6d13b9f5432827b7f3c7a314b8056b90f74869fb4161c1ac51fec536f58107943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Amniotic Fluid - metabolism</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Chromogranin A</topic><topic>Chromogranins - blood</topic><topic>Chromogranins - metabolism</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Labor, Obstetric - metabolism</topic><topic>Longitudinal Studies</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>online_resources</toplevel><creatorcontrib>FLORIO, Pasquale</creatorcontrib><creatorcontrib>MEZZESIMI, Alessandra</creatorcontrib><creatorcontrib>TURCHETTI, Vera</creatorcontrib><creatorcontrib>SEVERI, Filiberto Maria</creatorcontrib><creatorcontrib>TICCONI, Carlo</creatorcontrib><creatorcontrib>FORCONI, Sandro</creatorcontrib><creatorcontrib>PETRAGLIA, Felice</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Society for Gynecologic Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FLORIO, Pasquale</au><au>MEZZESIMI, Alessandra</au><au>TURCHETTI, Vera</au><au>SEVERI, Filiberto Maria</au><au>TICCONI, Carlo</au><au>FORCONI, Sandro</au><au>PETRAGLIA, Felice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition</atitle><jtitle>Journal of the Society for Gynecologic Investigation</jtitle><addtitle>J Soc Gynecol Investig</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>9</volume><issue>1</issue><spage>32</spage><epage>36</epage><pages>32-36</pages><issn>1071-5576</issn><eissn>1556-7117</eissn><abstract>The human placenta is a neuroendocrine organ that produces several hypothalamic and pituitary hormones that are secreted during pregnancy and parturition into maternal and fetal circulation and amniotic fluid. Human chromogranin A (CgA) is a glycoprotein mainly localized to the adrenal medulla and released in response to several stressful events. During pregnancy, intrauterine tissues express and synthesize CgA mRNA and peptide and secret it into the biologic fluids of pregnancy, so we investigated whether maternal, umbilical, and amniotic human CgA levels are affected by the stress of parturition.
We measured pregnancy CgA levels in maternal and umbilical cord plasma and in amniotic fluid at term (39-40 weeks), by enzyme-linked immunosorbent assay at elective cesarean (n = 16), after spontaneous vaginal delivery (n = 12), and longitudinally throughout labor and 2 hours postpartum.
CgA levels were highest in umbilical cord blood (P <.001). Umbilical cord plasma and amniotic fluid CgA levels were significantly higher at spontaneous vaginal delivery than at cesarean (P <.001), and the levels were not changed in maternal plasma according to cervical dilatation and postpartum.
The present findings showed that the stress of parturition increased CgA levels in umbilical cord plasma and amniotic fluid and was probably of fetal origin. Whatever the mode of delivery, CgA levels in infants were much more elevated than in mothers, providing evidence for an unusual and sustained high level of sympathoadrenal stimulation in full-term neonates.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>11839506</pmid><doi>10.1016/s1071-5576(01)00149-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the Society for Gynecologic Investigation, 2002-01, Vol.9 (1), p.32-36 |
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| subjects | Adult Amniotic Fluid - metabolism Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Cesarean Section Chromogranin A Chromogranins - blood Chromogranins - metabolism Female Fetal Blood - metabolism Gynecology. Andrology. Obstetrics Human bacterial diseases Humans Infant, Newborn Infectious diseases Labor, Obstetric - metabolism Longitudinal Studies Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy. Fetus. Placenta |
| title | High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition |
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