DNA Analogues: From Supramolecular Principles to Biological Properties
Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & Medicinal Chemistry 2002-04, Vol.10 (4), p.841-854 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 854 |
|---|---|
| container_issue | 4 |
| container_start_page | 841 |
| container_title | Bioorganic & Medicinal Chemistry |
| container_volume | 10 |
| creator | Leumann, Christian J. |
| description | Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A paticularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
A review on structure–activity relationships for a series of carbohydrate modified oligonucleotide analogues. |
| doi_str_mv | 10.1016/S0968-0896(01)00348-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71444850</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0968089601003480</els_id><sourcerecordid>71444850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-690d0944417876375bb345b91979889531348979adc1a6ca00fd3663ccdb6a4a3</originalsourceid><addsrcrecordid>eNqFkEFPwyAUx4nR6Jx-BE0vGj1UH0Jp8WLmdGqyqMn0TCilBtOOCq2J3166Ne7oiUf4vcf__RA6wnCBAbPLBXCWxZBxdgb4HIDQcNtCI0wZjQnheBuN_pA9tO_9JwBcUY530R7GGWHAYYRmd8-TaLKUlf3otL-OZs7W0aJrnKxtpVVXSRe9OrNUpqm0j1ob3RobYKNkFR5so11rtD9AO6WsvD4czjF6n92_TR_j-cvD03Qyj1VI1MaMQwGcUorTLGUkTfKc0CTnmKc8y3hCcFgj1LJQWDIlAcqCMEaUKnImqSRjdLqe2zj7FQK3ojZe6aqSS207L1IchmcJBDBZg8pZ750uReNMLd2PwCB6gWIlUPR2BGCxEij6vuPhgy6vdbHpGowF4GQApA8OSieDG7_hCE15ynruZs3poOPbaCe8MnqpdGGcVq0orPknyi8Ecosl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71444850</pqid></control><display><type>article</type><title>DNA Analogues: From Supramolecular Principles to Biological Properties</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Leumann, Christian J.</creator><creatorcontrib>Leumann, Christian J.</creatorcontrib><description>Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A paticularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
A review on structure–activity relationships for a series of carbohydrate modified oligonucleotide analogues.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/S0968-0896(01)00348-0</identifier><identifier>PMID: 11836090</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; DNA - chemical synthesis ; DNA - chemistry ; Drug Design ; Medical sciences ; Miscellaneous ; Molecular Mimicry ; Nucleic Acid Conformation ; Nucleosides - chemical synthesis ; Nucleosides - chemistry ; Oligonucleotides - chemical synthesis ; Oligonucleotides - chemistry ; Pharmacology. Drug treatments</subject><ispartof>Bioorganic & Medicinal Chemistry, 2002-04, Vol.10 (4), p.841-854</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-690d0944417876375bb345b91979889531348979adc1a6ca00fd3663ccdb6a4a3</citedby><cites>FETCH-LOGICAL-c391t-690d0944417876375bb345b91979889531348979adc1a6ca00fd3663ccdb6a4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089601003480$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13479760$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11836090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leumann, Christian J.</creatorcontrib><title>DNA Analogues: From Supramolecular Principles to Biological Properties</title><title>Bioorganic & Medicinal Chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A paticularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
A review on structure–activity relationships for a series of carbohydrate modified oligonucleotide analogues.</description><subject>Biological and medical sciences</subject><subject>DNA - chemical synthesis</subject><subject>DNA - chemistry</subject><subject>Drug Design</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Molecular Mimicry</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleosides - chemical synthesis</subject><subject>Nucleosides - chemistry</subject><subject>Oligonucleotides - chemical synthesis</subject><subject>Oligonucleotides - chemistry</subject><subject>Pharmacology. Drug treatments</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPwyAUx4nR6Jx-BE0vGj1UH0Jp8WLmdGqyqMn0TCilBtOOCq2J3166Ne7oiUf4vcf__RA6wnCBAbPLBXCWxZBxdgb4HIDQcNtCI0wZjQnheBuN_pA9tO_9JwBcUY530R7GGWHAYYRmd8-TaLKUlf3otL-OZs7W0aJrnKxtpVVXSRe9OrNUpqm0j1ob3RobYKNkFR5so11rtD9AO6WsvD4czjF6n92_TR_j-cvD03Qyj1VI1MaMQwGcUorTLGUkTfKc0CTnmKc8y3hCcFgj1LJQWDIlAcqCMEaUKnImqSRjdLqe2zj7FQK3ojZe6aqSS207L1IchmcJBDBZg8pZ750uReNMLd2PwCB6gWIlUPR2BGCxEij6vuPhgy6vdbHpGowF4GQApA8OSieDG7_hCE15ynruZs3poOPbaCe8MnqpdGGcVq0orPknyi8Ecosl</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Leumann, Christian J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>DNA Analogues: From Supramolecular Principles to Biological Properties</title><author>Leumann, Christian J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-690d0944417876375bb345b91979889531348979adc1a6ca00fd3663ccdb6a4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>DNA - chemical synthesis</topic><topic>DNA - chemistry</topic><topic>Drug Design</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Molecular Mimicry</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleosides - chemical synthesis</topic><topic>Nucleosides - chemistry</topic><topic>Oligonucleotides - chemical synthesis</topic><topic>Oligonucleotides - chemistry</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leumann, Christian J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & Medicinal Chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leumann, Christian J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA Analogues: From Supramolecular Principles to Biological Properties</atitle><jtitle>Bioorganic & Medicinal Chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>10</volume><issue>4</issue><spage>841</spage><epage>854</epage><pages>841-854</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A paticularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.
A review on structure–activity relationships for a series of carbohydrate modified oligonucleotide analogues.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11836090</pmid><doi>10.1016/S0968-0896(01)00348-0</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & Medicinal Chemistry, 2002-04, Vol.10 (4), p.841-854 |
| issn | 0968-0896 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71444850 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences DNA - chemical synthesis DNA - chemistry Drug Design Medical sciences Miscellaneous Molecular Mimicry Nucleic Acid Conformation Nucleosides - chemical synthesis Nucleosides - chemistry Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Pharmacology. Drug treatments |
| title | DNA Analogues: From Supramolecular Principles to Biological Properties |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T22%3A04%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DNA%20Analogues:%20From%20Supramolecular%20Principles%20to%20Biological%20Properties&rft.jtitle=Bioorganic%20&%20Medicinal%20Chemistry&rft.au=Leumann,%20Christian%20J.&rft.date=2002-04-01&rft.volume=10&rft.issue=4&rft.spage=841&rft.epage=854&rft.pages=841-854&rft.issn=0968-0896&rft.eissn=1464-3391&rft_id=info:doi/10.1016/S0968-0896(01)00348-0&rft_dat=%3Cproquest_cross%3E71444850%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71444850&rft_id=info:pmid/11836090&rft_els_id=S0968089601003480&rfr_iscdi=true |