Composite Hodgkin lymphoma and mantle cell lymphoma: Two clonally unrelated tumors
Association of Hodgkin lymphoma and non-Hodgkin lymphoma is rare and, specifically, the combination of Hodgkin lymphoma and mantle cell lymphoma has not been previously described. Here we describe composite mantle cell lymphoma and Hodgkin lymphoma affecting the spleen in one case and the eyelid and...
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| Veröffentlicht in: | The American journal of surgical pathology 2003-12, Vol.27 (12), p.1577-1580 |
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| container_title | The American journal of surgical pathology |
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| creator | CALEO, Alessia SANCHEZ-AGUILERA, Abel RODRIGUEZ, Sandra DOTOR, Ana M BELTRAN, Luis DE LARRINOA, Aitor F MENARGUEZ, Francisco J PIRIS, Miguel A GARCIA, Juan F |
| description | Association of Hodgkin lymphoma and non-Hodgkin lymphoma is rare and, specifically, the combination of Hodgkin lymphoma and mantle cell lymphoma has not been previously described. Here we describe composite mantle cell lymphoma and Hodgkin lymphoma affecting the spleen in one case and the eyelid and cervical lymph nodes in a second. In both, nodules of classical Hodgkin lymphoma were intermixed with diffuse or nodular areas of typical mantle cell lymphoma. Immunohistochemical and molecular analyses confirmed cyclin D1 overexpression secondary to the translocation t(11;14) in the small mantle cell lymphoma component; with CD30, CD15, and EBV expression in the Hodgkin and Reed-Sternberg cells. Finally, clonal analysis of rearranged immunoglobulin genes performed on microdissected Hodgkin and Reed-Sternberg and mantle cell lymphoma cells provided definite evidence of separate clonal origins of the two tumors in the patients. These EBV-positive, clonally unrelated tumors seem to represent true composite neoplasms, in contrast to cases showing merely clonal progression. |
| doi_str_mv | 10.1097/00000478-200312000-00012 |
| format | Article |
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Here we describe composite mantle cell lymphoma and Hodgkin lymphoma affecting the spleen in one case and the eyelid and cervical lymph nodes in a second. In both, nodules of classical Hodgkin lymphoma were intermixed with diffuse or nodular areas of typical mantle cell lymphoma. Immunohistochemical and molecular analyses confirmed cyclin D1 overexpression secondary to the translocation t(11;14) in the small mantle cell lymphoma component; with CD30, CD15, and EBV expression in the Hodgkin and Reed-Sternberg cells. Finally, clonal analysis of rearranged immunoglobulin genes performed on microdissected Hodgkin and Reed-Sternberg and mantle cell lymphoma cells provided definite evidence of separate clonal origins of the two tumors in the patients. These EBV-positive, clonally unrelated tumors seem to represent true composite neoplasms, in contrast to cases showing merely clonal progression.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/00000478-200312000-00012</identifier><identifier>PMID: 14657719</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Animals ; Biological and medical sciences ; Epstein-Barr Virus Infections ; Gene Rearrangement, B-Lymphocyte, Heavy Chain ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human ; Hodgkin Disease - etiology ; Hodgkin Disease - pathology ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lasers ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Mantle-Cell - etiology ; Lymphoma, Mantle-Cell - pathology ; Male ; Medical sciences ; Microdissection ; Middle Aged ; Neoplasms, Second Primary - etiology ; Neoplasms, Second Primary - pathology ; Polymerase Chain Reaction ; Reed-Sternberg Cells - physiology ; Reed-Sternberg Cells - virology ; Translocation, Genetic</subject><ispartof>The American journal of surgical pathology, 2003-12, Vol.27 (12), p.1577-1580</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c286t-32ac33e343fa1903928d6a53e88fdd833ff6cec27c3ea1c03b148221f71e1b1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15321032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14657719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CALEO, Alessia</creatorcontrib><creatorcontrib>SANCHEZ-AGUILERA, Abel</creatorcontrib><creatorcontrib>RODRIGUEZ, Sandra</creatorcontrib><creatorcontrib>DOTOR, Ana M</creatorcontrib><creatorcontrib>BELTRAN, Luis</creatorcontrib><creatorcontrib>DE LARRINOA, Aitor F</creatorcontrib><creatorcontrib>MENARGUEZ, Francisco J</creatorcontrib><creatorcontrib>PIRIS, Miguel A</creatorcontrib><creatorcontrib>GARCIA, Juan F</creatorcontrib><title>Composite Hodgkin lymphoma and mantle cell lymphoma: Two clonally unrelated tumors</title><title>The American journal of surgical pathology</title><addtitle>Am J Surg Pathol</addtitle><description>Association of Hodgkin lymphoma and non-Hodgkin lymphoma is rare and, specifically, the combination of Hodgkin lymphoma and mantle cell lymphoma has not been previously described. Here we describe composite mantle cell lymphoma and Hodgkin lymphoma affecting the spleen in one case and the eyelid and cervical lymph nodes in a second. In both, nodules of classical Hodgkin lymphoma were intermixed with diffuse or nodular areas of typical mantle cell lymphoma. Immunohistochemical and molecular analyses confirmed cyclin D1 overexpression secondary to the translocation t(11;14) in the small mantle cell lymphoma component; with CD30, CD15, and EBV expression in the Hodgkin and Reed-Sternberg cells. Finally, clonal analysis of rearranged immunoglobulin genes performed on microdissected Hodgkin and Reed-Sternberg and mantle cell lymphoma cells provided definite evidence of separate clonal origins of the two tumors in the patients. These EBV-positive, clonally unrelated tumors seem to represent true composite neoplasms, in contrast to cases showing merely clonal progression.</description><subject>Aged</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Epstein-Barr Virus Infections</subject><subject>Gene Rearrangement, B-Lymphocyte, Heavy Chain</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human</subject><subject>Hodgkin Disease - etiology</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lasers</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Mantle-Cell - etiology</subject><subject>Lymphoma, Mantle-Cell - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdissection</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Reed-Sternberg Cells - physiology</subject><subject>Reed-Sternberg Cells - virology</subject><subject>Translocation, Genetic</subject><issn>0147-5185</issn><issn>1532-0979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkVFLwzAQgIMobk7_guRF36q5XNukvslQJwwEmc8lS1Otps1MWmT_3tbV7SB3D_nuLnwhhAK7AZaJWzZELGTEGUPoE4v6A_yITCFBHvVMdkymDGIRJSCTCTkL4XMgJPBTMoE4TYSAbEpe567euFC1hi5c8f5VNdRu682HqxVVTUFr1bTWUG2s3V_c0dWPo9q6Rlm7pV3jjVWtKWjb1c6Hc3JSKhvMxVhn5O3xYTVfRMuXp-f5_TLSXKZthFxpRIMxlgoyhhmXRaoSNFKWRSERyzLVRnOh0SjQDNcQS86hFGBgDRpn5Ho3d-Pdd2dCm9dVGB6qGuO6kAuIYxSZ6EG5A7V3IXhT5htf1cpvc2D54DP_95nvfeZ_PvvWy3FHt65NcWgcBfbA1QiooJUtvWp0FQ5c_xvAkOMvHFh9tA</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>CALEO, Alessia</creator><creator>SANCHEZ-AGUILERA, Abel</creator><creator>RODRIGUEZ, Sandra</creator><creator>DOTOR, Ana M</creator><creator>BELTRAN, Luis</creator><creator>DE LARRINOA, Aitor F</creator><creator>MENARGUEZ, Francisco J</creator><creator>PIRIS, Miguel A</creator><creator>GARCIA, Juan F</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Composite Hodgkin lymphoma and mantle cell lymphoma: Two clonally unrelated tumors</title><author>CALEO, Alessia ; SANCHEZ-AGUILERA, Abel ; RODRIGUEZ, Sandra ; DOTOR, Ana M ; BELTRAN, Luis ; DE LARRINOA, Aitor F ; MENARGUEZ, Francisco J ; PIRIS, Miguel A ; GARCIA, Juan F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-32ac33e343fa1903928d6a53e88fdd833ff6cec27c3ea1c03b148221f71e1b1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Epstein-Barr Virus Infections</topic><topic>Gene Rearrangement, B-Lymphocyte, Heavy Chain</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human</topic><topic>Hodgkin Disease - etiology</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lasers</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Mantle-Cell - etiology</topic><topic>Lymphoma, Mantle-Cell - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdissection</topic><topic>Middle Aged</topic><topic>Neoplasms, Second Primary - etiology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Polymerase Chain Reaction</topic><topic>Reed-Sternberg Cells - physiology</topic><topic>Reed-Sternberg Cells - virology</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CALEO, Alessia</creatorcontrib><creatorcontrib>SANCHEZ-AGUILERA, Abel</creatorcontrib><creatorcontrib>RODRIGUEZ, Sandra</creatorcontrib><creatorcontrib>DOTOR, Ana M</creatorcontrib><creatorcontrib>BELTRAN, Luis</creatorcontrib><creatorcontrib>DE LARRINOA, Aitor F</creatorcontrib><creatorcontrib>MENARGUEZ, Francisco J</creatorcontrib><creatorcontrib>PIRIS, Miguel A</creatorcontrib><creatorcontrib>GARCIA, Juan F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CALEO, Alessia</au><au>SANCHEZ-AGUILERA, Abel</au><au>RODRIGUEZ, Sandra</au><au>DOTOR, Ana M</au><au>BELTRAN, Luis</au><au>DE LARRINOA, Aitor F</au><au>MENARGUEZ, Francisco J</au><au>PIRIS, Miguel A</au><au>GARCIA, Juan F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Composite Hodgkin lymphoma and mantle cell lymphoma: Two clonally unrelated tumors</atitle><jtitle>The American journal of surgical pathology</jtitle><addtitle>Am J Surg Pathol</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>27</volume><issue>12</issue><spage>1577</spage><epage>1580</epage><pages>1577-1580</pages><issn>0147-5185</issn><eissn>1532-0979</eissn><coden>AJSPDX</coden><abstract>Association of Hodgkin lymphoma and non-Hodgkin lymphoma is rare and, specifically, the combination of Hodgkin lymphoma and mantle cell lymphoma has not been previously described. Here we describe composite mantle cell lymphoma and Hodgkin lymphoma affecting the spleen in one case and the eyelid and cervical lymph nodes in a second. In both, nodules of classical Hodgkin lymphoma were intermixed with diffuse or nodular areas of typical mantle cell lymphoma. Immunohistochemical and molecular analyses confirmed cyclin D1 overexpression secondary to the translocation t(11;14) in the small mantle cell lymphoma component; with CD30, CD15, and EBV expression in the Hodgkin and Reed-Sternberg cells. Finally, clonal analysis of rearranged immunoglobulin genes performed on microdissected Hodgkin and Reed-Sternberg and mantle cell lymphoma cells provided definite evidence of separate clonal origins of the two tumors in the patients. These EBV-positive, clonally unrelated tumors seem to represent true composite neoplasms, in contrast to cases showing merely clonal progression.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14657719</pmid><doi>10.1097/00000478-200312000-00012</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Animals Biological and medical sciences Epstein-Barr Virus Infections Gene Rearrangement, B-Lymphocyte, Heavy Chain Hematologic and hematopoietic diseases Herpesvirus 4, Human Hodgkin Disease - etiology Hodgkin Disease - pathology Humans Immunohistochemistry Immunophenotyping In Situ Hybridization, Fluorescence Lasers Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Mantle-Cell - etiology Lymphoma, Mantle-Cell - pathology Male Medical sciences Microdissection Middle Aged Neoplasms, Second Primary - etiology Neoplasms, Second Primary - pathology Polymerase Chain Reaction Reed-Sternberg Cells - physiology Reed-Sternberg Cells - virology Translocation, Genetic |
| title | Composite Hodgkin lymphoma and mantle cell lymphoma: Two clonally unrelated tumors |
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