Cisplatin augments cytotoxic T-lymphocyte–mediated antitumor immunity in poorly immunogenic murine lung cancer

Many tumors are poorly immunogenic and resistant to cytotoxic T-lymphocyte–mediated cell lysis. Because cisplatin has been demonstrated to increase tumor cell Fas receptor expression, we hypothesized that cisplatin will enhance cytotoxic T-lymphocyte tumor cell killing and augment the antitumor effe...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2003-11, Vol.126 (5), p.1609-1617
Hauptverfasser:	Merritt, Robert E, Mahtabifard, Ali, Yamada, Reiko E, Crystal, Ronald G, Korst, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Antineoplastic agents Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - therapy CD40 Ligand Chemotherapy Cisplatin - pharmacology fas Receptor - drug effects fas Receptor - immunology Female Flow Cytometry Fluorescent Antibody Technique Gene Transfer Techniques Genetic Vectors Immunotherapy, Adoptive - methods Injections, Intraperitoneal keywords: 9 Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Probability Sensitivity and Specificity Statistics, Nonparametric Survival Rate T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Up-Regulation
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