Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel

Voltage-gated L-type Ca(2+) channels (LCCs) provide Ca(2+) ingress into cardiac myocytes and play a key role in intracellular Ca(2+) homeostasis and excitation-contraction coupling. We investigated the effects of a constitutive increase of LCC density on Ca(2+) signaling in ventricular myocytes from...

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Veröffentlicht in:	Circulation research 2002-02, Vol.90 (2), p.174-181
Hauptverfasser:	Song, Long-Sheng, Guia, António, Muth, James N, Rubio, Marta, Wang, Shi-Qiang, Xiao, Rui-Ping, Josephson, Ira R, Lakatta, Edward G, Schwartz, Arnold, Cheng, Heping
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Caffeine - pharmacology Calcium - metabolism Calcium Channels, L-Type - biosynthesis Calcium Channels, L-Type - genetics Calcium Signaling - drug effects Calcium Signaling - physiology Calcium-Binding Proteins - metabolism Calcium-Transporting ATPases - metabolism Cardiac Pacing, Artificial Cardiomegaly - genetics Cardiomegaly - metabolism Cell Separation Cytosol - metabolism Homeostasis In Vitro Techniques Mice Mice, Transgenic Myocardium - cytology Myocardium - metabolism Patch-Clamp Techniques Protein Subunits Ryanodine Receptor Calcium Release Channel - metabolism Sarcolemma - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases Sodium-Calcium Exchanger - metabolism
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