Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

Inhibitors of histone deacetylase (HDAC) have been shown to induce terminal differentiation of human tumor cell lines and to have antitumor effects in vivo. We have prepared analogues of suberoylanilide hydroxamic acid (SAHA) and trichostatin A and have evaluated them in a human HDAC enzyme inhibiti...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-02, Vol.45 (4), p.753-757
Hauptverfasser:	Remiszewski, Stacy W, Sambucetti, Lidia C, Atadja, Peter, Bair, Kenneth W, Cornell, Wendy D, Green, Michael A, Howell, Kobporn Lulu, Jung, Manfred, Kwon, Paul, Trogani, Nancy, Walker, Heather
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Biological and medical sciences Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Drug Screening Assays, Antitumor Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Histone Deacetylase Inhibitors Humans Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Hydroxylamines - chemical synthesis Hydroxylamines - chemistry Hydroxylamines - pharmacology Medical sciences Models, Molecular Pharmacology. Drug treatments Promoter Regions, Genetic Structure-Activity Relationship Tumor Cells, Cultured
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