Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions
Studies in Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects o...
Gespeichert in:
| Veröffentlicht in: | Developmental cell 2002-02, Vol.2 (2), p.239-249 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 2 |
| container_start_page | 239 |
| container_title | Developmental cell |
| container_volume | 2 |
| creator | Britton, Jessica S. Lockwood, Wendy K. Li, Ling Cohen, Stephen M. Edgar, Bruce A. |
| description | Studies in
Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level. Consistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion as an indicator for PI3K activity show that PI3K is regulated by the availability of dietary protein in vivo. Hence we surmise that an essential function of insulin/PI3K signaling in
Drosophila is to coordinate cellular metabolism with nutritional conditions. |
| doi_str_mv | 10.1016/S1534-5807(02)00117-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71440890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S153458070200117X</els_id><sourcerecordid>18295312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406x-488b96d9cd8cfec55c2796763ea32ce7679db79e69160aae27c340213f08dcd93</originalsourceid><addsrcrecordid>eNqFkU1PGzEQhi1ExVf7E1rtidLDgsfe9ccJVWkLEbRFKkjcLMeeKK4269TeLeXfY5KgHjnNaPS8M6P3JeQ90FOgIM5-QcubulVUnlD2iVIAWd_vkANQUtXQtrBb-hdknxzm_LtAAhTdI_sAijPW6APivqSY42oROvsxV9M-j13oz26mvL4Kvc1Y3dhh8WAfq0mMyZfRgLmaYNeNnU3VdxzsLHYhL6uHMCyqH-OQwhBib7si6P26z2_Jm7ntMr7b1iNy9-3r7eSyvv55MZ18vq5dQ8W_ulFqpoXXzis3R9e2jkktpOBoOXMohdR-JjUKDYJai0w63lAGfE6Vd17zI3K82btK8c-IeTDLkF351fYYx2wkNA1Vmr4KgmK65cAK2G5AV1zKCedmlcLSpkcD1DzHYNYxmGePDWVmHYO5L7oP2wPjbIn-v2rrewHONwAWP_4GTCa7gL1DHxK6wfgYXjnxBOEJmFQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18295312</pqid></control><display><type>article</type><title>Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Britton, Jessica S. ; Lockwood, Wendy K. ; Li, Ling ; Cohen, Stephen M. ; Edgar, Bruce A.</creator><creatorcontrib>Britton, Jessica S. ; Lockwood, Wendy K. ; Li, Ling ; Cohen, Stephen M. ; Edgar, Bruce A.</creatorcontrib><description>Studies in
Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level. Consistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion as an indicator for PI3K activity show that PI3K is regulated by the availability of dietary protein in vivo. Hence we surmise that an essential function of insulin/PI3K signaling in
Drosophila is to coordinate cellular metabolism with nutritional conditions.</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/S1534-5807(02)00117-X</identifier><identifier>PMID: 11832249</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3-kinase ; Amino Acid Sequence ; Animal Nutritional Physiological Phenomena ; Animals ; Animals, Genetically Modified ; Blood Proteins - chemistry ; Blood Proteins - genetics ; Cell Division - drug effects ; Dietary Proteins - metabolism ; Dietary Proteins - pharmacology ; Drosophila ; Drosophila - cytology ; Drosophila - drug effects ; Drosophila - growth & development ; Drosophila - metabolism ; Fat Body - drug effects ; Fat Body - enzymology ; Fat Body - growth & development ; Fat Body - metabolism ; Feeding Behavior ; Insulin - metabolism ; Larva - cytology ; Larva - drug effects ; Larva - growth & development ; Larva - metabolism ; Molecular Sequence Data ; Phenotype ; Phosphatidylinositol 3-Kinases - antagonists & inhibitors ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphoproteins - chemistry ; Phosphoproteins - genetics ; Protein Structure, Tertiary ; Receptor, Insulin - metabolism ; Signal Transduction - drug effects ; Starvation - metabolism ; Stomach - cytology ; Stomach - drug effects ; Stomach - growth & development ; Stomach - metabolism ; Survival Rate ; Transgenes - genetics</subject><ispartof>Developmental cell, 2002-02, Vol.2 (2), p.239-249</ispartof><rights>2002 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406x-488b96d9cd8cfec55c2796763ea32ce7679db79e69160aae27c340213f08dcd93</citedby><cites>FETCH-LOGICAL-c406x-488b96d9cd8cfec55c2796763ea32ce7679db79e69160aae27c340213f08dcd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S153458070200117X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11832249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Britton, Jessica S.</creatorcontrib><creatorcontrib>Lockwood, Wendy K.</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Cohen, Stephen M.</creatorcontrib><creatorcontrib>Edgar, Bruce A.</creatorcontrib><title>Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>Studies in
Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level. Consistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion as an indicator for PI3K activity show that PI3K is regulated by the availability of dietary protein in vivo. Hence we surmise that an essential function of insulin/PI3K signaling in
Drosophila is to coordinate cellular metabolism with nutritional conditions.</description><subject>3-kinase</subject><subject>Amino Acid Sequence</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Blood Proteins - chemistry</subject><subject>Blood Proteins - genetics</subject><subject>Cell Division - drug effects</subject><subject>Dietary Proteins - metabolism</subject><subject>Dietary Proteins - pharmacology</subject><subject>Drosophila</subject><subject>Drosophila - cytology</subject><subject>Drosophila - drug effects</subject><subject>Drosophila - growth & development</subject><subject>Drosophila - metabolism</subject><subject>Fat Body - drug effects</subject><subject>Fat Body - enzymology</subject><subject>Fat Body - growth & development</subject><subject>Fat Body - metabolism</subject><subject>Feeding Behavior</subject><subject>Insulin - metabolism</subject><subject>Larva - cytology</subject><subject>Larva - drug effects</subject><subject>Larva - growth & development</subject><subject>Larva - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Phenotype</subject><subject>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphoproteins - chemistry</subject><subject>Phosphoproteins - genetics</subject><subject>Protein Structure, Tertiary</subject><subject>Receptor, Insulin - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Starvation - metabolism</subject><subject>Stomach - cytology</subject><subject>Stomach - drug effects</subject><subject>Stomach - growth & development</subject><subject>Stomach - metabolism</subject><subject>Survival Rate</subject><subject>Transgenes - genetics</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhi1ExVf7E1rtidLDgsfe9ccJVWkLEbRFKkjcLMeeKK4269TeLeXfY5KgHjnNaPS8M6P3JeQ90FOgIM5-QcubulVUnlD2iVIAWd_vkANQUtXQtrBb-hdknxzm_LtAAhTdI_sAijPW6APivqSY42oROvsxV9M-j13oz26mvL4Kvc1Y3dhh8WAfq0mMyZfRgLmaYNeNnU3VdxzsLHYhL6uHMCyqH-OQwhBib7si6P26z2_Jm7ntMr7b1iNy9-3r7eSyvv55MZ18vq5dQ8W_ulFqpoXXzis3R9e2jkktpOBoOXMohdR-JjUKDYJai0w63lAGfE6Vd17zI3K82btK8c-IeTDLkF351fYYx2wkNA1Vmr4KgmK65cAK2G5AV1zKCedmlcLSpkcD1DzHYNYxmGePDWVmHYO5L7oP2wPjbIn-v2rrewHONwAWP_4GTCa7gL1DHxK6wfgYXjnxBOEJmFQ</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Britton, Jessica S.</creator><creator>Lockwood, Wendy K.</creator><creator>Li, Ling</creator><creator>Cohen, Stephen M.</creator><creator>Edgar, Bruce A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>200202</creationdate><title>Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions</title><author>Britton, Jessica S. ; Lockwood, Wendy K. ; Li, Ling ; Cohen, Stephen M. ; Edgar, Bruce A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406x-488b96d9cd8cfec55c2796763ea32ce7679db79e69160aae27c340213f08dcd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>3-kinase</topic><topic>Amino Acid Sequence</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Blood Proteins - chemistry</topic><topic>Blood Proteins - genetics</topic><topic>Cell Division - drug effects</topic><topic>Dietary Proteins - metabolism</topic><topic>Dietary Proteins - pharmacology</topic><topic>Drosophila</topic><topic>Drosophila - cytology</topic><topic>Drosophila - drug effects</topic><topic>Drosophila - growth & development</topic><topic>Drosophila - metabolism</topic><topic>Fat Body - drug effects</topic><topic>Fat Body - enzymology</topic><topic>Fat Body - growth & development</topic><topic>Fat Body - metabolism</topic><topic>Feeding Behavior</topic><topic>Insulin - metabolism</topic><topic>Larva - cytology</topic><topic>Larva - drug effects</topic><topic>Larva - growth & development</topic><topic>Larva - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Phenotype</topic><topic>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Phosphoproteins - chemistry</topic><topic>Phosphoproteins - genetics</topic><topic>Protein Structure, Tertiary</topic><topic>Receptor, Insulin - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Starvation - metabolism</topic><topic>Stomach - cytology</topic><topic>Stomach - drug effects</topic><topic>Stomach - growth & development</topic><topic>Stomach - metabolism</topic><topic>Survival Rate</topic><topic>Transgenes - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Britton, Jessica S.</creatorcontrib><creatorcontrib>Lockwood, Wendy K.</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Cohen, Stephen M.</creatorcontrib><creatorcontrib>Edgar, Bruce A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Britton, Jessica S.</au><au>Lockwood, Wendy K.</au><au>Li, Ling</au><au>Cohen, Stephen M.</au><au>Edgar, Bruce A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2002-02</date><risdate>2002</risdate><volume>2</volume><issue>2</issue><spage>239</spage><epage>249</epage><pages>239-249</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>Studies in
Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level. Consistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion as an indicator for PI3K activity show that PI3K is regulated by the availability of dietary protein in vivo. Hence we surmise that an essential function of insulin/PI3K signaling in
Drosophila is to coordinate cellular metabolism with nutritional conditions.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11832249</pmid><doi>10.1016/S1534-5807(02)00117-X</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1534-5807 |
| ispartof | Developmental cell, 2002-02, Vol.2 (2), p.239-249 |
| issn | 1534-5807 1878-1551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71440890 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 3-kinase Amino Acid Sequence Animal Nutritional Physiological Phenomena Animals Animals, Genetically Modified Blood Proteins - chemistry Blood Proteins - genetics Cell Division - drug effects Dietary Proteins - metabolism Dietary Proteins - pharmacology Drosophila Drosophila - cytology Drosophila - drug effects Drosophila - growth & development Drosophila - metabolism Fat Body - drug effects Fat Body - enzymology Fat Body - growth & development Fat Body - metabolism Feeding Behavior Insulin - metabolism Larva - cytology Larva - drug effects Larva - growth & development Larva - metabolism Molecular Sequence Data Phenotype Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - chemistry Phosphoproteins - genetics Protein Structure, Tertiary Receptor, Insulin - metabolism Signal Transduction - drug effects Starvation - metabolism Stomach - cytology Stomach - drug effects Stomach - growth & development Stomach - metabolism Survival Rate Transgenes - genetics |
| title | Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T09%3A24%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drosophila's%20Insulin/PI3-Kinase%20Pathway%20Coordinates%20Cellular%20Metabolism%20with%20Nutritional%20Conditions&rft.jtitle=Developmental%20cell&rft.au=Britton,%20Jessica%20S.&rft.date=2002-02&rft.volume=2&rft.issue=2&rft.spage=239&rft.epage=249&rft.pages=239-249&rft.issn=1534-5807&rft.eissn=1878-1551&rft_id=info:doi/10.1016/S1534-5807(02)00117-X&rft_dat=%3Cproquest_cross%3E18295312%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18295312&rft_id=info:pmid/11832249&rft_els_id=S153458070200117X&rfr_iscdi=true |