Mechanism of the Glutathione Transferase-Catalyzed Conversion of Antitumor 2-Crotonyloxymethyl-2-cycloalkenones to GSH Adducts

Human glutathione (GSH) transferase (hGSTP1-1) processes with similar kinetic efficiencies the antitumor agents 2-crotonyloxymethyl-2-cyclohexenone (COMC-6), 2-crotonyloxymethyl-2-cycloheptenone (COMC-7), and 2-crotonyloxymethyl-2-cyclopentenone (COMC-5) to 2-glutathionylmethyl-2-cyclohexenone, 2-gl...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-12, Vol.125 (49), p.15049-15058
Hauptverfasser:	Hamilton, Diana S, Zhang, Xiyun, Ding, Zhebo, Hubatsch, Ina, Mannervik, Bengt, Houk, K. N, Ganem, Bruce, Creighton, Donald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Biological and medical sciences Cyclohexanones - chemistry Cyclohexanones - metabolism Cyclohexanones - pharmacokinetics General pharmacology Glutathione - chemistry Glutathione - metabolism Glutathione S-Transferase pi Glutathione Transferase - chemistry Glutathione Transferase - metabolism Humans Isoenzymes - chemistry Isoenzymes - metabolism Kinetics Medical sciences Models, Molecular Molecular Conformation Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Stereoisomerism Substrate Specificity Thermodynamics
Online-Zugang:	Volltext
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