Expression of p53 and Prognosis in Children with Malignant Gliomas

The clinical and histologic features of high-grade gliomas in children are not always useful prognostic indicators. This study investigated the prognostic usefulness of evaluating gliomas in children for the presence of p53, a protein involved in numerous aspects of the life and death of a cell. Chi...

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Veröffentlicht in:	The New England journal of medicine 2002-02, Vol.346 (6), p.420-427
Hauptverfasser:	Pollack, Ian F, Finkelstein, Sydney D, Woods, Jeffrey, Burnham, Judith, Holmes, Emiko J, Hamilton, Ronald L, Yates, Allan J, Boyett, James M, Finlay, Jonathan L, Sposto, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Child Child, Preschool Children & youth Disease-Free Survival DNA Mutational Analysis Genes, p53 Genetic engineering Glioma - genetics Glioma - metabolism Glioma - pathology Humans Infant Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mutation Nervous system Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pediatrics Prognosis Studies Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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