In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy

Specific immunotherapy (SIT) acts by inducing a shift from T H2 to T H1 cell response on mucous membranes, reducing allergic inflammation. New genes expressed primarily in T H1-type cells have been found. Of these genes, signaling lymphocytic activation molecule (SLAM) promotes T-cell proliferation...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2003-12, Vol.112 (6), p.1171-1177
Hauptverfasser:	Laaksonen, Kirsi, Junikka, Miia, Lahesmaa, Riitta, Terho, Erkki O, Savolainen, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult allergen-induced Allergens - administration & dosage Allergens - immunology Allergies Antigens, CD Autoimmune diseases Betula - immunology Cell growth Desensitization, Immunologic Female Glycoproteins - genetics Glycoproteins - metabolism Humans IL-12Rβ2 Immunoglobulins - genetics Immunoglobulins - metabolism Leukocytes, Mononuclear Lymphocyte Activation Male Phleum - immunology Plant Extracts - administration & dosage Plant Extracts - immunology Pollen Pollen - immunology Quality of life Receptors, Cell Surface Receptors, Interleukin - genetics Receptors, Interleukin - metabolism Receptors, Interleukin-12 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signaling Lymphocytic Activation Molecule Family Member 1 SLAM Specific immunotherapy T-bet T-Box Domain Proteins Transcription Factors - genetics Transcription Factors - metabolism Treatment Outcome
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