VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection

A lack of productive HIV-1 infection of Kit225 compared to Jurkat T cells, despite similar levels of CD4 and HIV-1 chemokine co-receptors, was found to correlate with the expression of vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor-1 (VPAC1). We therefore e...

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Veröffentlicht in:	AIDS (London) 2002-02, Vol.16 (3), p.309-319
Hauptverfasser:	BRANCH, Donald R, VALENTA, Linda J. E, YOUSEFI, Shida, SAKAC, Darinka, SINGLA, Ruchi, BALI, Meenakshi, SAHAI, Beni M, MA, Xue-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Biological and medical sciences Cell Line DNA, Antisense - genetics DNA, Antisense - pharmacology DNA, Complementary - genetics Gene Expression HIV Envelope Protein gp120 - immunology HIV Infections - etiology HIV Infections - prevention & control HIV Long Terminal Repeat HIV-1 - pathogenicity Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Jurkat Cells Medical sciences Receptors, Vasoactive Intestinal Peptide - antagonists & inhibitors Receptors, Vasoactive Intestinal Peptide - genetics Receptors, Vasoactive Intestinal Peptide - physiology Receptors, Vasoactive Intestinal Polypeptide, Type I Reverse Transcriptase Polymerase Chain Reaction Signal Transduction T-Lymphocytes - physiology T-Lymphocytes - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids VPAC1 protein
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