ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression

Extracellular ATP released from axons is known to assist activity-dependent signaling between neurons and Schwann cells in the peripheral nervous system. Here we report that ATP released from astrocytes as a result of neuronal activity can also modulate central synaptic transmission. In cultures of...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-12, Vol.40 (5), p.971-982
Hauptverfasser:	Zhang, Jing-ming, Wang, Hui-kun, Ye, Chang-quan, Ge, Wooping, Chen, Yiren, Jiang, Zheng-lin, Wu, Chien-ping, Poo, Mu-ming, Duan, Shumin
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adenosine triphosphatase Adenosine Triphosphate - metabolism Adenosine Triphosphate - physiology Animals Astrocytes - metabolism Astrocytes - physiology Cell culture Cells, Cultured Glutamic Acid - metabolism Hippocampus - metabolism Neural Inhibition - physiology Neurons Rats Rats, Sprague-Dawley Rodents Synapses - metabolism Synaptic Transmission - physiology
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