A study of retrieved allografts used to replace anterior cruciate ligaments
Purpose: The purpose of the study was the examination of retrieved whole anterior cruciate ligament (ACL) replacement grafts to determine the rate and the extent of cellular replacement and remodeling of the grafts. Type of Study: Gross and histopathologic examination of specimens. Methods: Nine spe...
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| Veröffentlicht in: | Arthroscopy 2002-02, Vol.18 (2), p.163-170 |
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| creator | Malinin, Theodore I. Levitt, Richard L. Bashore, Christopher Temple, H.Thomas Mnaymneh, Walid |
| description | Purpose: The purpose of the study was the examination of retrieved whole anterior cruciate ligament (ACL) replacement grafts to determine the rate and the extent of cellular replacement and remodeling of the grafts. Type of Study: Gross and histopathologic examination of specimens. Methods: Nine specimens of ACL replacement allografts and 1 autograft were obtained at autopsy and surgical procedures. Results: Examination of these specimens from 20 days to 10 years after transplantation revealed a pattern of revascularization similar to that reported in previous biopsy studies. However, examination of the entire allografts showed that, at 2 years after transplantation, the central portions of the grafts remained acellular and that complete attachment was not present, but was found in a 3.5-year post-transplantation specimen. Conclusions: Because attachment of the graft to bone tunnel walls required over 2 years, the tunnel remodeling may be explained on a mechanical basis. The remodeling of ACL replacement grafts is a gradual or slow process. Complete remodeling and cellular replacement of the entire graft may require 3 years or longer.
Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 18, No 2 (February), 2002: pp 163–170 |
| doi_str_mv | 10.1053/jars.2002.30485 |
| format | Article |
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Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 18, No 2 (February), 2002: pp 163–170</description><subject>Achilles Tendon - pathology</subject><subject>Achilles Tendon - transplantation</subject><subject>ACL</subject><subject>Adult</subject><subject>Aged</subject><subject>Allograft</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Histology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leg Bones - anatomy & histology</subject><subject>Leg Bones - blood supply</subject><subject>Leg Bones - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoarticular system. Muscles</subject><subject>Patellar Ligament - pathology</subject><subject>Patellar Ligament - transplantation</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Remodeling</subject><subject>Replacement</subject><subject>Retrieval</subject><subject>Time Factors</subject><subject>Transplantation, Homologous - pathology</subject><issn>0749-8063</issn><issn>1526-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiMEYuPjzA31ArcOJ26a9jghvsQkLnCOstRBQV07knQS_56OTdqJiy3Lj19ZD2NXHGYcJN59mRBnAkDMEIpKHrEpl6LMUSA_ZlNQRZ1XUOKEncX4BQCIFZ6yCecVQsVhyl7nWUxD85P1LguUgqcNNZlp2_4zGJdiNsRxTv24XLfGUma6RMH3IbNhsN4kylr_aVbUpXjBTpxpI13u-zn7eHx4v3_OF29PL_fzRW5RYcpL5KIGCaasl7aSIHCJwhlqVKmaEsZaFEtX2pq7um7IKUmKpBDWEVdkFJ6z213uOvTfA8WkVz5aalvTUT9ErXiBFVQwgnc70IY-xkBOr4NfmfCjOeitP731p7f-9J-_8eJ6Hz0sV9Qc-L2wEbjZAyZa07pgOuvjgUMpuFT1yNU7jkYRG09BR-ups9T4QDbppvf_PvELIveMOA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Malinin, Theodore I.</creator><creator>Levitt, Richard L.</creator><creator>Bashore, Christopher</creator><creator>Temple, H.Thomas</creator><creator>Mnaymneh, Walid</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>A study of retrieved allografts used to replace anterior cruciate ligaments</title><author>Malinin, Theodore I. ; Levitt, Richard L. ; Bashore, Christopher ; Temple, H.Thomas ; Mnaymneh, Walid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-63129050a69bc85023b32faed767d6076744bf6c91f99def75e7e522cfe17ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Achilles Tendon - pathology</topic><topic>Achilles Tendon - transplantation</topic><topic>ACL</topic><topic>Adult</topic><topic>Aged</topic><topic>Allograft</topic><topic>Anterior Cruciate Ligament - surgery</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Histology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leg Bones - anatomy & histology</topic><topic>Leg Bones - blood supply</topic><topic>Leg Bones - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoarticular system. Muscles</topic><topic>Patellar Ligament - pathology</topic><topic>Patellar Ligament - transplantation</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Remodeling</topic><topic>Replacement</topic><topic>Retrieval</topic><topic>Time Factors</topic><topic>Transplantation, Homologous - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malinin, Theodore I.</creatorcontrib><creatorcontrib>Levitt, Richard L.</creatorcontrib><creatorcontrib>Bashore, Christopher</creatorcontrib><creatorcontrib>Temple, H.Thomas</creatorcontrib><creatorcontrib>Mnaymneh, Walid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malinin, Theodore I.</au><au>Levitt, Richard L.</au><au>Bashore, Christopher</au><au>Temple, H.Thomas</au><au>Mnaymneh, Walid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of retrieved allografts used to replace anterior cruciate ligaments</atitle><jtitle>Arthroscopy</jtitle><addtitle>Arthroscopy</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>18</volume><issue>2</issue><spage>163</spage><epage>170</epage><pages>163-170</pages><issn>0749-8063</issn><eissn>1526-3231</eissn><coden>ARTHE3</coden><abstract>Purpose: The purpose of the study was the examination of retrieved whole anterior cruciate ligament (ACL) replacement grafts to determine the rate and the extent of cellular replacement and remodeling of the grafts. Type of Study: Gross and histopathologic examination of specimens. Methods: Nine specimens of ACL replacement allografts and 1 autograft were obtained at autopsy and surgical procedures. Results: Examination of these specimens from 20 days to 10 years after transplantation revealed a pattern of revascularization similar to that reported in previous biopsy studies. However, examination of the entire allografts showed that, at 2 years after transplantation, the central portions of the grafts remained acellular and that complete attachment was not present, but was found in a 3.5-year post-transplantation specimen. Conclusions: Because attachment of the graft to bone tunnel walls required over 2 years, the tunnel remodeling may be explained on a mechanical basis. The remodeling of ACL replacement grafts is a gradual or slow process. Complete remodeling and cellular replacement of the entire graft may require 3 years or longer.
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| subjects | Achilles Tendon - pathology Achilles Tendon - transplantation ACL Adult Aged Allograft Anterior Cruciate Ligament - surgery Biological and medical sciences Female Histology Humans Investigative techniques, diagnostic techniques (general aspects) Leg Bones - anatomy & histology Leg Bones - blood supply Leg Bones - surgery Male Medical sciences Middle Aged Osteoarticular system. Muscles Patellar Ligament - pathology Patellar Ligament - transplantation Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Remodeling Replacement Retrieval Time Factors Transplantation, Homologous - pathology |
| title | A study of retrieved allografts used to replace anterior cruciate ligaments |
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