A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility

It has long been speculated that intracellular pH is a critical regulator of both invertebrate and vertebrate sperm motility 1 , 2 , 3 , and sodium–hydrogen exchange has been suggested as a mediator of such pH i regulation in various instances 4 , 5 . Two sodium–hydrogen exchangers (NHE1 and NHE5) a...

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Veröffentlicht in:	Nature cell biology 2003-12, Vol.5 (12), p.1117-1122
Hauptverfasser:	Wang, Dan, King, Shelby M., Quill, Timothy A., Doolittle, Lynda K., Garbers, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonium Ammonium Chloride - pharmacology Animals Biomedical and Life Sciences Cancer Research Cell Biology Cell Membrane - drug effects Cell Membrane - enzymology Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Developmental Biology DNA, Complementary - analysis DNA, Complementary - genetics Female Fertility Fertility - physiology Histology Hydrogen Hydrogen-Ion Concentration - drug effects Infertility Intracellular Fluid - drug effects Intracellular Fluid - metabolism Invertebrates letter Life Sciences Male Mice Microscopy Molecular Sequence Data Mutation - genetics Protein Structure, Tertiary - physiology Publishing Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Sodium Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - isolation & purification Sperm Sperm Motility - physiology Spermatozoa - metabolism Stem Cells Vertebrates
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