Serotonin receptors: guardians of stable breathing
Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain disease...
Gespeichert in:
| Veröffentlicht in: | Trends in molecular medicine 2003-12, Vol.9 (12), p.542-548 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 548 |
|---|---|
| container_issue | 12 |
| container_start_page | 542 |
| container_title | Trends in molecular medicine |
| container_volume | 9 |
| creator | Richter, Diethelm W Manzke, Till Wilken, Bernd Ponimaskin, Evgeni |
| description | Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients. |
| doi_str_mv | 10.1016/j.molmed.2003.10.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71436041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71436041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-ec3c3586ed1b81d0349a6557f26471a9339462668ec443bd9ac60a56f029dd8f3</originalsourceid><addsrcrecordid>eNo9kE9PhDAUxHvQuOvqNzCGkzewj5ZCvZmN_5JNPKjnprSPlQ1QbOHgtxcC8fSSeTOTyY-QG6AJUBD3p6R1TYs2SSllk5RQoGdkCzyHmEvgG3IZwolSyPK8uCAb4CKTXMgtST_Qu8F1dRd5NNgPzoeH6Dhqb2vdhchVURh02WBUetTDd90dr8h5pZuA1-vdka_np8_9a3x4f3nbPx5iw4QcYjTMsKwQaKEswFLGpRZZllepmGZpydi0IBWiQMM5K63URlCdiYqm0tqiYjtyt_T23v2MGAbV1sFg0-gO3RhUDpwJymEy8sVovAvBY6V6X7fa_yqgauajTmrho2Y-szrxmWK3a_9Yzr__0AqH_QETWGRf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71436041</pqid></control><display><type>article</type><title>Serotonin receptors: guardians of stable breathing</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Richter, Diethelm W ; Manzke, Till ; Wilken, Bernd ; Ponimaskin, Evgeni</creator><creatorcontrib>Richter, Diethelm W ; Manzke, Till ; Wilken, Bernd ; Ponimaskin, Evgeni</creatorcontrib><description>Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.</description><identifier>ISSN: 1471-4914</identifier><identifier>DOI: 10.1016/j.molmed.2003.10.010</identifier><identifier>PMID: 14659469</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Brain - pathology ; Humans ; Models, Biological ; Receptors, Serotonin - metabolism ; Receptors, Serotonin - physiology ; Respiration ; Respiration Disorders - pathology ; Serotonin - metabolism ; Signal Transduction</subject><ispartof>Trends in molecular medicine, 2003-12, Vol.9 (12), p.542-548</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-ec3c3586ed1b81d0349a6557f26471a9339462668ec443bd9ac60a56f029dd8f3</citedby><cites>FETCH-LOGICAL-c369t-ec3c3586ed1b81d0349a6557f26471a9339462668ec443bd9ac60a56f029dd8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14659469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richter, Diethelm W</creatorcontrib><creatorcontrib>Manzke, Till</creatorcontrib><creatorcontrib>Wilken, Bernd</creatorcontrib><creatorcontrib>Ponimaskin, Evgeni</creatorcontrib><title>Serotonin receptors: guardians of stable breathing</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.</description><subject>Animals</subject><subject>Brain - pathology</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Receptors, Serotonin - physiology</subject><subject>Respiration</subject><subject>Respiration Disorders - pathology</subject><subject>Serotonin - metabolism</subject><subject>Signal Transduction</subject><issn>1471-4914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9PhDAUxHvQuOvqNzCGkzewj5ZCvZmN_5JNPKjnprSPlQ1QbOHgtxcC8fSSeTOTyY-QG6AJUBD3p6R1TYs2SSllk5RQoGdkCzyHmEvgG3IZwolSyPK8uCAb4CKTXMgtST_Qu8F1dRd5NNgPzoeH6Dhqb2vdhchVURh02WBUetTDd90dr8h5pZuA1-vdka_np8_9a3x4f3nbPx5iw4QcYjTMsKwQaKEswFLGpRZZllepmGZpydi0IBWiQMM5K63URlCdiYqm0tqiYjtyt_T23v2MGAbV1sFg0-gO3RhUDpwJymEy8sVovAvBY6V6X7fa_yqgauajTmrho2Y-szrxmWK3a_9Yzr__0AqH_QETWGRf</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Richter, Diethelm W</creator><creator>Manzke, Till</creator><creator>Wilken, Bernd</creator><creator>Ponimaskin, Evgeni</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Serotonin receptors: guardians of stable breathing</title><author>Richter, Diethelm W ; Manzke, Till ; Wilken, Bernd ; Ponimaskin, Evgeni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-ec3c3586ed1b81d0349a6557f26471a9339462668ec443bd9ac60a56f029dd8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Brain - pathology</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Receptors, Serotonin - physiology</topic><topic>Respiration</topic><topic>Respiration Disorders - pathology</topic><topic>Serotonin - metabolism</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richter, Diethelm W</creatorcontrib><creatorcontrib>Manzke, Till</creatorcontrib><creatorcontrib>Wilken, Bernd</creatorcontrib><creatorcontrib>Ponimaskin, Evgeni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richter, Diethelm W</au><au>Manzke, Till</au><au>Wilken, Bernd</au><au>Ponimaskin, Evgeni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin receptors: guardians of stable breathing</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>9</volume><issue>12</issue><spage>542</spage><epage>548</epage><pages>542-548</pages><issn>1471-4914</issn><abstract>Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.</abstract><cop>England</cop><pmid>14659469</pmid><doi>10.1016/j.molmed.2003.10.010</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4914 |
| ispartof | Trends in molecular medicine, 2003-12, Vol.9 (12), p.542-548 |
| issn | 1471-4914 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71436041 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Brain - pathology Humans Models, Biological Receptors, Serotonin - metabolism Receptors, Serotonin - physiology Respiration Respiration Disorders - pathology Serotonin - metabolism Signal Transduction |
| title | Serotonin receptors: guardians of stable breathing |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T11%3A30%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serotonin%20receptors:%20guardians%20of%20stable%20breathing&rft.jtitle=Trends%20in%20molecular%20medicine&rft.au=Richter,%20Diethelm%20W&rft.date=2003-12-01&rft.volume=9&rft.issue=12&rft.spage=542&rft.epage=548&rft.pages=542-548&rft.issn=1471-4914&rft_id=info:doi/10.1016/j.molmed.2003.10.010&rft_dat=%3Cproquest_cross%3E71436041%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71436041&rft_id=info:pmid/14659469&rfr_iscdi=true |