The Relationship between Riboflavin and Plasma Total Homocysteine in the Framingham Offspring Cohort Is Influenced by Folate Status and the C677T Transition in the Methylenetetrahydrofolate Reductase Gene

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Because MTHFR c...

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Veröffentlicht in:	The Journal of nutrition 2002-02, Vol.132 (2), p.283-288
Hauptverfasser:	Jacques, Paul F., Kalmbach, Renee, Bagley, Pamela J., Russo, Giuseppina T., Rogers, Gail, Rosenberg, Irwin H., Selhub, Jacob, Wilson, Peter W.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenine Biological and medical sciences Cohort Studies Cross-Sectional Studies Epidemiology Fasting Female folate folic acid Folic Acid - blood genes Genotype homocysteine Homocysteine - blood Homocysteine - metabolism homozygosity Homozygote Humans Male metabolism methionine Methylation methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Mutation nucleotides Nutrition Oxidoreductases Acting on CH-NH Group Donors - genetics Oxidoreductases Acting on CH-NH Group Donors - metabolism people Plasma progeny prostheses Proteins riboflavin Riboflavin - blood
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