Effects of Urinary Trypsin Inhibitor in Patients at Risk for Premature Labor with a Bulging Fetal Membrane
Objective: To investigate the effect of urinary trypsin inhibitor (UTI) in patients at risk for premature labor with bulging membrane. Methods: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the...
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| Veröffentlicht in: | Fetal diagnosis and therapy 2002-03, Vol.17 (2), p.69-74 |
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| description | Objective: To investigate the effect of urinary trypsin inhibitor (UTI) in patients at risk for premature labor with bulging membrane. Methods: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the severity: those with a moderately developed bulging membrane like a ‘dome’ (dome type), and those with a membrane prolapsed into the vagina, resulting in an ‘hourglass’ shape (hourglass type). We compared the outcomes of treatment with or without UTI (UTI group versus non-UTI group) in each type. Gestational age at delivery, birth weight, prolongation time from admission to delivery, and neonatal mortality rate were examined in each group. Results: A total of 43 patients with a bulging membrane were analyzed. In 21 patients with the dome type, gestational age at delivery (the UTI group versus the non-UTI group; 30.4 ± 5.0 versus 26.4 ± 1.9 weeks, p < 0.05), birth weight (1,436.8 ± 708.3 versus 882.8 ± 261.6 g, p < 0.05) and neonatal mortality rate (0/13 versus 3/8, p < 0.05) were all significantly improved by the use of UTI. On the other hand, in 22 patients with the hourglass type, there was no significant difference between the UTI group and the non-UTI group. The overall prevalence of histological chorioamnionitis was 60%. Conclusion: These results suggest that UTI therapy is very effective in patients at risk for premature labor with a moderately developed bulging membrane during the second trimester. |
| doi_str_mv | 10.1159/000048011 |
| format | Article |
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Methods: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the severity: those with a moderately developed bulging membrane like a ‘dome’ (dome type), and those with a membrane prolapsed into the vagina, resulting in an ‘hourglass’ shape (hourglass type). We compared the outcomes of treatment with or without UTI (UTI group versus non-UTI group) in each type. Gestational age at delivery, birth weight, prolongation time from admission to delivery, and neonatal mortality rate were examined in each group. Results: A total of 43 patients with a bulging membrane were analyzed. In 21 patients with the dome type, gestational age at delivery (the UTI group versus the non-UTI group; 30.4 ± 5.0 versus 26.4 ± 1.9 weeks, p < 0.05), birth weight (1,436.8 ± 708.3 versus 882.8 ± 261.6 g, p < 0.05) and neonatal mortality rate (0/13 versus 3/8, p < 0.05) were all significantly improved by the use of UTI. On the other hand, in 22 patients with the hourglass type, there was no significant difference between the UTI group and the non-UTI group. The overall prevalence of histological chorioamnionitis was 60%. Conclusion: These results suggest that UTI therapy is very effective in patients at risk for premature labor with a moderately developed bulging membrane during the second trimester.</description><identifier>ISSN: 1015-3837</identifier><identifier>EISSN: 1421-9964</identifier><identifier>DOI: 10.1159/000048011</identifier><identifier>PMID: 11844908</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Birth Weight ; Chorioamnionitis - complications ; Diseases of mother, fetus and pregnancy ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Extraembryonic Membranes - pathology ; Female ; Gestational Age ; Glycoproteins - therapeutic use ; Gynecology. Andrology. Obstetrics ; Humans ; Infant Mortality ; Infant, Newborn ; Infant, Premature ; Intensive care medicine ; Medical sciences ; Obstetric Labor, Premature - prevention & control ; Pregnancy ; Pregnancy Complications ; Pregnancy. Fetus. Placenta ; Prolapse ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>Fetal diagnosis and therapy, 2002-03, Vol.17 (2), p.69-74</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright (c) 2002 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-c344ea660f95b4c2af42c6cf9d9e5d065ef2d130bc4ece031313d83e92a9edb23</citedby><cites>FETCH-LOGICAL-c385t-c344ea660f95b4c2af42c6cf9d9e5d065ef2d130bc4ece031313d83e92a9edb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13495739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11844908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuda, Yoshio</creatorcontrib><creatorcontrib>Yunohara, Naoki</creatorcontrib><title>Effects of Urinary Trypsin Inhibitor in Patients at Risk for Premature Labor with a Bulging Fetal Membrane</title><title>Fetal diagnosis and therapy</title><addtitle>Fetal Diagn Ther</addtitle><description>Objective: To investigate the effect of urinary trypsin inhibitor (UTI) in patients at risk for premature labor with bulging membrane. Methods: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the severity: those with a moderately developed bulging membrane like a ‘dome’ (dome type), and those with a membrane prolapsed into the vagina, resulting in an ‘hourglass’ shape (hourglass type). We compared the outcomes of treatment with or without UTI (UTI group versus non-UTI group) in each type. Gestational age at delivery, birth weight, prolongation time from admission to delivery, and neonatal mortality rate were examined in each group. Results: A total of 43 patients with a bulging membrane were analyzed. In 21 patients with the dome type, gestational age at delivery (the UTI group versus the non-UTI group; 30.4 ± 5.0 versus 26.4 ± 1.9 weeks, p < 0.05), birth weight (1,436.8 ± 708.3 versus 882.8 ± 261.6 g, p < 0.05) and neonatal mortality rate (0/13 versus 3/8, p < 0.05) were all significantly improved by the use of UTI. On the other hand, in 22 patients with the hourglass type, there was no significant difference between the UTI group and the non-UTI group. The overall prevalence of histological chorioamnionitis was 60%. Conclusion: These results suggest that UTI therapy is very effective in patients at risk for premature labor with a moderately developed bulging membrane during the second trimester.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Chorioamnionitis - complications</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Extraembryonic Membranes - pathology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Glycoproteins - therapeutic use</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - prevention & control</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prolapse</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1015-3837</issn><issn>1421-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0NtLHDEUB-BQKtXaPvgslCBY8GHb3CY7eVTrqrClUtbnIZM5WbPOZU0yiP99T7urgjSBXD9Owo-QA86-cV6Y7wybKhnn78geV4JPjNHqPa4ZLyaylNNd8jGlFapyKvUHsst5qZRh5R5ZXXgPLic6eHobQ2_jE13Ep3UKPb3u70Id8hApbm5sDtAjtJn-Dumeejy_idDZPEagc1vj_jHkO2rp2dguQ7-kM8i2pT-hq6Pt4RPZ8bZN8Hk775Pb2cXi_Goy_3V5fX46nzhZFhlHpcBqzbwpauWE9Uo47bxpDBQN0wV40XDJaqfAAZMce1NKMMIaaGoh98nXTd11HB5GSLnqQnLQtviHYUzVlCupSi4RHr2Bq2GMPf6tEkJIrbnSiE42yMUhpQi-WsfQYUwVZ9Xf9KuX9NF-2RYc6w6aV7mNG8HxFtjkbOsxFhfSq5PKFFNp0B1u3L2NS4gv4PmZo__ezn4s_oFq3Xj5B2Sfn_s</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Matsuda, Yoshio</creator><creator>Yunohara, Naoki</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Effects of Urinary Trypsin Inhibitor in Patients at Risk for Premature Labor with a Bulging Fetal Membrane</title><author>Matsuda, Yoshio ; Yunohara, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-c344ea660f95b4c2af42c6cf9d9e5d065ef2d130bc4ece031313d83e92a9edb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Chorioamnionitis - complications</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Extraembryonic Membranes - pathology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Glycoproteins - therapeutic use</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - prevention & control</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prolapse</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuda, Yoshio</creatorcontrib><creatorcontrib>Yunohara, Naoki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Fetal diagnosis and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuda, Yoshio</au><au>Yunohara, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Urinary Trypsin Inhibitor in Patients at Risk for Premature Labor with a Bulging Fetal Membrane</atitle><jtitle>Fetal diagnosis and therapy</jtitle><addtitle>Fetal Diagn Ther</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>17</volume><issue>2</issue><spage>69</spage><epage>74</epage><pages>69-74</pages><issn>1015-3837</issn><eissn>1421-9964</eissn><abstract>Objective: To investigate the effect of urinary trypsin inhibitor (UTI) in patients at risk for premature labor with bulging membrane. Methods: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the severity: those with a moderately developed bulging membrane like a ‘dome’ (dome type), and those with a membrane prolapsed into the vagina, resulting in an ‘hourglass’ shape (hourglass type). We compared the outcomes of treatment with or without UTI (UTI group versus non-UTI group) in each type. Gestational age at delivery, birth weight, prolongation time from admission to delivery, and neonatal mortality rate were examined in each group. Results: A total of 43 patients with a bulging membrane were analyzed. In 21 patients with the dome type, gestational age at delivery (the UTI group versus the non-UTI group; 30.4 ± 5.0 versus 26.4 ± 1.9 weeks, p < 0.05), birth weight (1,436.8 ± 708.3 versus 882.8 ± 261.6 g, p < 0.05) and neonatal mortality rate (0/13 versus 3/8, p < 0.05) were all significantly improved by the use of UTI. On the other hand, in 22 patients with the hourglass type, there was no significant difference between the UTI group and the non-UTI group. The overall prevalence of histological chorioamnionitis was 60%. Conclusion: These results suggest that UTI therapy is very effective in patients at risk for premature labor with a moderately developed bulging membrane during the second trimester.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11844908</pmid><doi>10.1159/000048011</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Birth Weight Chorioamnionitis - complications Diseases of mother, fetus and pregnancy Emergency and intensive care: neonates and children. Prematurity. Sudden death Extraembryonic Membranes - pathology Female Gestational Age Glycoproteins - therapeutic use Gynecology. Andrology. Obstetrics Humans Infant Mortality Infant, Newborn Infant, Premature Intensive care medicine Medical sciences Obstetric Labor, Premature - prevention & control Pregnancy Pregnancy Complications Pregnancy. Fetus. Placenta Prolapse Risk Factors Time Factors Treatment Outcome |
| title | Effects of Urinary Trypsin Inhibitor in Patients at Risk for Premature Labor with a Bulging Fetal Membrane |
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