PYY-mediated fatty acid induced intestinal differentiation

An essential process for fatty acid digestion, absorption and assimilation is the constant replacement of mature intestinal epithelial cells by differentiating stem cells. Free fatty acids (FFA) and PYY may act in concert to alter mucosal cell differentiation through the cytoskeletal-extracellular m...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2002-02, Vol.23 (2), p.367-376
1. Verfasser:	Aponte, Gregory W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Cell Adhesion Cell Differentiation Cell Movement Cytoskeleton - metabolism Epithelial Cells - metabolism Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins Fatty Acids - metabolism Humans Intestinal Mucosa - metabolism Intestines - cytology Neoplasm Proteins Peptide YY - metabolism Signal Transduction Tumor Suppressor Proteins
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Beschreibung
Zusammenfassung:	An essential process for fatty acid digestion, absorption and assimilation is the constant replacement of mature intestinal epithelial cells by differentiating stem cells. Free fatty acids (FFA) and PYY may act in concert to alter mucosal cell differentiation through the cytoskeletal-extracellular matrix interactions. PYY induced expression of tetraspanins and intestinal fatty acid binding protein (I-FABP) may be part of a mechanism whereby FFA modulate expression of differentiation dependent proteins in the mucosa. This modulation provides a means for FFA to act as signal molecules in the feedback regulation of their own assimilation.
ISSN:	0196-9781
DOI:	10.1016/S0196-9781(01)00613-1