P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism
Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and comp...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2003-10, Vol.9 (4), p.309-316 |
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| creator | Inami, Norihito Nomura, Shosaku Kikuchi, Hiraku Kajiura, Takayuki Yamada, Kohichi Nakamori, Hisahito Takahashi, Nobuyuki Tsuda, Nobuyuki Hikosaka, Makoto Masaki, Motoko Iwasaka, Toshiji |
| description | Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells. |
| doi_str_mv | 10.1177/107602960300900406 |
| format | Article |
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These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/107602960300900406</identifier><identifier>PMID: 14653440</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee - adverse effects ; Biomarkers - analysis ; Blood Platelets - chemistry ; Blood Platelets - physiology ; Blood Platelets - ultrastructure ; Case-Control Studies ; Chemokines ; Chemokines - analysis ; Embolisms ; Female ; Heredity ; Humans ; Joint replacement surgery ; Joint surgery ; Male ; Membrane Microdomains ; Middle Aged ; Monocytes - physiology ; P-Selectin - analysis ; Particle Size ; Platelet Activation ; Platelet Aggregation Inhibitors - pharmacology ; Pulmonary Embolism - blood ; Pulmonary Embolism - etiology ; Pulmonary embolisms</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2003-10, Vol.9 (4), p.309-316</ispartof><rights>Copyright SAGE PUBLICATIONS, INC. 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These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Biomarkers - analysis</subject><subject>Blood Platelets - chemistry</subject><subject>Blood Platelets - physiology</subject><subject>Blood Platelets - ultrastructure</subject><subject>Case-Control Studies</subject><subject>Chemokines</subject><subject>Chemokines - analysis</subject><subject>Embolisms</subject><subject>Female</subject><subject>Heredity</subject><subject>Humans</subject><subject>Joint replacement surgery</subject><subject>Joint surgery</subject><subject>Male</subject><subject>Membrane Microdomains</subject><subject>Middle Aged</subject><subject>Monocytes - physiology</subject><subject>P-Selectin - analysis</subject><subject>Particle Size</subject><subject>Platelet Activation</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Pulmonary Embolism - blood</subject><subject>Pulmonary Embolism - etiology</subject><subject>Pulmonary embolisms</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkV1LHDEUhkOxVF37B3ohAcG7qSfJbD4uF7W24NK9qNdDNnOmjZ2ZrElG8aa_vZFZEFpor_LBc56Q9yXkA4OPjCl1wUBJ4EaCADAANcg35IgZoSuuuDgo-wJUL8QhOU7pHoAZaeQ7cshquRR1DUfk16ZK2KPLfqR2bOmmt7mcc3WF0T9iS9fexbCzMXvXY6KrlILzhWnpk88_6DqMwT1npKuieLTZh5GubfyJMdGi3JQbHHOa4c3UD2G08ZleD9vQ-zSckLed7RO-368Lcvfp-tvl5-r2682Xy9Vt5YTRuaoNWqj1cosdtAI6p7cahbKKM7ME5eYkOrfknWQCjZOsoEozaZRuhRULcj57dzE8TJhyM_jksO_tiGFKjWK1qIVQ_wU5gBas0Aty9gd4H6Y4lk80vETLNOcgCsVnqoSYUsSu2UU_lAQaBs1Lic3fJZah07162g7Yvo7sWyvAxQwk-x1f3_2H8jfE66TB</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Inami, Norihito</creator><creator>Nomura, Shosaku</creator><creator>Kikuchi, Hiraku</creator><creator>Kajiura, Takayuki</creator><creator>Yamada, Kohichi</creator><creator>Nakamori, Hisahito</creator><creator>Takahashi, Nobuyuki</creator><creator>Tsuda, Nobuyuki</creator><creator>Hikosaka, Makoto</creator><creator>Masaki, Motoko</creator><creator>Iwasaka, Toshiji</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism</title><author>Inami, Norihito ; Nomura, Shosaku ; Kikuchi, Hiraku ; Kajiura, Takayuki ; Yamada, Kohichi ; Nakamori, Hisahito ; Takahashi, Nobuyuki ; Tsuda, Nobuyuki ; Hikosaka, Makoto ; Masaki, Motoko ; Iwasaka, Toshiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-49ea0485bef0d30fc8b8e37a7219507c107602fc52f613e9c61bef7816978d3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Biomarkers - analysis</topic><topic>Blood Platelets - chemistry</topic><topic>Blood Platelets - physiology</topic><topic>Blood Platelets - ultrastructure</topic><topic>Case-Control Studies</topic><topic>Chemokines</topic><topic>Chemokines - analysis</topic><topic>Embolisms</topic><topic>Female</topic><topic>Heredity</topic><topic>Humans</topic><topic>Joint replacement surgery</topic><topic>Joint surgery</topic><topic>Male</topic><topic>Membrane Microdomains</topic><topic>Middle Aged</topic><topic>Monocytes - physiology</topic><topic>P-Selectin - analysis</topic><topic>Particle Size</topic><topic>Platelet Activation</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Pulmonary Embolism - blood</topic><topic>Pulmonary Embolism - etiology</topic><topic>Pulmonary embolisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inami, Norihito</creatorcontrib><creatorcontrib>Nomura, Shosaku</creatorcontrib><creatorcontrib>Kikuchi, Hiraku</creatorcontrib><creatorcontrib>Kajiura, Takayuki</creatorcontrib><creatorcontrib>Yamada, Kohichi</creatorcontrib><creatorcontrib>Nakamori, Hisahito</creatorcontrib><creatorcontrib>Takahashi, Nobuyuki</creatorcontrib><creatorcontrib>Tsuda, Nobuyuki</creatorcontrib><creatorcontrib>Hikosaka, Makoto</creatorcontrib><creatorcontrib>Masaki, Motoko</creatorcontrib><creatorcontrib>Iwasaka, Toshiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Inami, Norihito</au><au>Nomura, Shosaku</au><au>Kikuchi, Hiraku</au><au>Kajiura, Takayuki</au><au>Yamada, Kohichi</au><au>Nakamori, Hisahito</au><au>Takahashi, Nobuyuki</au><au>Tsuda, Nobuyuki</au><au>Hikosaka, Makoto</au><au>Masaki, Motoko</au><au>Iwasaka, Toshiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>9</volume><issue>4</issue><spage>309</spage><epage>316</epage><pages>309-316</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>14653440</pmid><doi>10.1177/107602960300900406</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2003-10, Vol.9 (4), p.309-316 |
| issn | 1076-0296 1938-2723 |
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| source | SAGE Journals |
| subjects | Adult Aged Aged, 80 and over Arthroplasty, Replacement, Knee - adverse effects Biomarkers - analysis Blood Platelets - chemistry Blood Platelets - physiology Blood Platelets - ultrastructure Case-Control Studies Chemokines Chemokines - analysis Embolisms Female Heredity Humans Joint replacement surgery Joint surgery Male Membrane Microdomains Middle Aged Monocytes - physiology P-Selectin - analysis Particle Size Platelet Activation Platelet Aggregation Inhibitors - pharmacology Pulmonary Embolism - blood Pulmonary Embolism - etiology Pulmonary embolisms |
| title | P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism |
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