Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

The ex vivo priming and expansion of human cytotoxic T lymphocytes (CTLs) has potential for use in immunotherapy applications for cancer and infectious diseases. To overcome the difficulty in obtaining sufficient numbers of CTLs, we have developed artificial antigen-presenting cells (aAPCs) expressi...

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Veröffentlicht in:	Nature biotechnology 2002-02, Vol.20 (2), p.143-148
Hauptverfasser:	June, Carl H, Maus, Marcela V, Thomas, Anna K, Leonard, Debra G.B, Allman, David, Addya, Kathakali, Schlienger, Katia, Riley, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	4-1BB antigen Agriculture Antibodies Antigen-Presenting Cells - immunology Antigens Antigens, CD Apoptosis Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cancer CD28 antigen CD28 Antigens - metabolism CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cell Line Cell Separation Cells, Cultured Cloning Coculture Techniques Cytomegalovirus Cytotoxicity Flow Cytometry Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Immunotherapy Immunotherapy, Adoptive - methods Industrial applications and implications. Economical aspects Infectious diseases K562 Cells Life Sciences Ligands Lymphocytes Medical research Miscellaneous Protein Binding Receptors, Antigen, T-Cell - metabolism Receptors, Nerve Growth Factor - metabolism Receptors, Tumor Necrosis Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology Time Factors Tumor Necrosis Factor Receptor Superfamily, Member 9 Tumor necrosis factor-TNF
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