MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits

The mechanism of spinal cord injury is believed to be related to the vulnerability of spinal motor neuron cells against ischemia. We tested whether MCI-186, which is useful for treating ischemic damage in the brain, can protect against ischemic spinal cord damage. After induction of ischemia, MCI-18...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2003-11, Vol.126 (5), p.1461-1466
Hauptverfasser:	Takahashi, Goro, Sakurai, Masahiro, Abe, Koji, Itoyama, Yasuto, Tabayashi, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipyrine - analogs & derivatives Antipyrine - pharmacology Biological and medical sciences Biopsy, Needle Disease Models, Animal General and cellular metabolism. Vitamins Immunohistochemistry Injections, Intravenous Ischemia - enzymology Ischemia - prevention & control keywords 19 Male Medical sciences Motor Neurons - drug effects Motor Neurons - pathology Nitric Oxide Synthase - analysis Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I Pharmacology. Drug treatments Rabbits Random Allocation Reference Values Sensitivity and Specificity Spinal Cord Injuries - enzymology Spinal Cord Injuries - pathology Spinal Cord Injuries - prevention & control Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism
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