CYP1A2 activity is an important determinant of clozapine dosage in schizophrenic patients

Clozapine is an effective atypical antipsychotic drug applied in the treatment of resistant schizophrenia. The drug is mainly metabolized by cytochrome P-450 (CYP) enzymes especially the isozyme CYP1A2. Remarkably, the effective dosage varies widely among patients, making it necessary to individuali...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2003-12, Vol.20 (4), p.451-457
Hauptverfasser:	Doude van Troostwijk, Lous J.A.E, Koopmans, Richard P, Vermeulen, Hans D.B, Guchelaar, Henk-Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - pharmacology Biological and medical sciences Caffeine - pharmacology Clozapine - administration & dosage Clozapine - pharmacokinetics Clozapine - pharmacology Clozapine dose Clozapine metabolism CYP1A2 activity Cytochrome P-450 CYP1A2 - metabolism Female Humans Male Medical sciences Middle Aged Neuropharmacology Pharmacokinetics Pharmacology. Drug treatments Phenotype Phosphodiesterase Inhibitors - pharmacology Psychiatric Status Rating Scales Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Schizophrenia - drug therapy Schizophrenia - metabolism Xanthines - metabolism
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