The Structure of Chorismate Synthase Reveals a Novel Flavin Binding Site Fundamental to a Unique Chemical Reaction

The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 Å resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential the...

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Veröffentlicht in:	Structure (London) 2003-12, Vol.11 (12), p.1499-1511
Hauptverfasser:	Maclean, John, Ali, Sohail
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Catalysis chorismate synthase Crystallography, X-Ray Dimerization Escherichia coli - metabolism flavin Flavins - chemistry Kinetics Models, Chemical Models, Molecular Molecular Sequence Data Organophosphorus Compounds - chemistry Phosphorus-Oxygen Lyases - chemistry Protein Binding Protein Conformation Protein Structure, Secondary Sequence Homology, Amino Acid Streptococcus pneumoniae Streptococcus pneumoniae - enzymology
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