Ketoacidosis at onset of type 1 diabetes mellitus in children - frequency and clinical presentation
: Background: Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden‐Wuerttemberg (BW), Germany. Aim: Our aim was to describe the frequency and the clinical presentation of diabetic ketoacidosis (DKA) at onset of type 1 diabetes mellitus...
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| Veröffentlicht in: | Pediatric diabetes 2003-06, Vol.4 (2), p.77-81 |
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| container_title | Pediatric diabetes |
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| creator | Neu, Andreas Willasch, Andre Ehehalt, Stefan Hub, Regine Ranke, Michael B. |
| description | : Background: Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden‐Wuerttemberg (BW), Germany.
Aim: Our aim was to describe the frequency and the clinical presentation of diabetic ketoacidosis (DKA) at onset of type 1 diabetes mellitus in children.
Methods: All 31 pediatric departments in BW and one diabetes center participated in this study. Hospital records of 2121 children below 15 yr of age were examined retrospectively. DKA was defined as glucose > 250 mg/dL, pH |
| doi_str_mv | 10.1034/j.1399-5448.2003.00007.x |
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Aim: Our aim was to describe the frequency and the clinical presentation of diabetic ketoacidosis (DKA) at onset of type 1 diabetes mellitus in children.
Methods: All 31 pediatric departments in BW and one diabetes center participated in this study. Hospital records of 2121 children below 15 yr of age were examined retrospectively. DKA was defined as glucose > 250 mg/dL, pH < 7.30 or bicarbonate < 15 mmol/L and ketonuria. Statistical analysis was done after logarithmic transformation.
Results: 26.3% (n = 558) of all patients presented with DKA. The mean age of these patients was 7.9 yr. The frequency of DKA is higher in girls than in boys (28.9 vs. 23.8%; p = 0.0079). Those aged 0–4 yr suffered most frequently (p < 0.0001) from ketoacidosis (36.0%). The percentage of DKA in newly diagnosed cases was constant over 10 yr. 23.3% of all patients with DKA presented with an altered level of consciousness; 10.9% of these had clinical signs of coma. No deaths occurred. The proportion of ketoacidosis does not increase concurrently with the number of diabetes manifestations in winter.
Conclusion: The proportion of DKA in children with newly diagnosed diabetes mellitus is significant. In particular, children < 5 yr and girls face an increased risk. DKA may be the result of a particularly aggressive subtype of diabetes.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1034/j.1399-5448.2003.00007.x</identifier><identifier>PMID: 14655263</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Age Factors ; Child ; Child, Preschool ; children ; diabetes mellitus ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetic Ketoacidosis - epidemiology ; Female ; Germany - epidemiology ; Humans ; Incidence ; incidence registry ; Infant ; ketoacidosis ; Male ; Retrospective Studies ; Severity of Illness Index ; Sex Characteristics ; subtype</subject><ispartof>Pediatric diabetes, 2003-06, Vol.4 (2), p.77-81</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3197-48a9f7c7f01b9fb3ff9cfe338b01ab4f8858fdc13197f455dbf8124601ce029d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1399-5448.2003.00007.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-5448.2003.00007.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14655263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neu, Andreas</creatorcontrib><creatorcontrib>Willasch, Andre</creatorcontrib><creatorcontrib>Ehehalt, Stefan</creatorcontrib><creatorcontrib>Hub, Regine</creatorcontrib><creatorcontrib>Ranke, Michael B.</creatorcontrib><creatorcontrib>DIARY Group Baden-Wuerttemberg</creatorcontrib><title>Ketoacidosis at onset of type 1 diabetes mellitus in children - frequency and clinical presentation</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>: Background: Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden‐Wuerttemberg (BW), Germany.
Aim: Our aim was to describe the frequency and the clinical presentation of diabetic ketoacidosis (DKA) at onset of type 1 diabetes mellitus in children.
Methods: All 31 pediatric departments in BW and one diabetes center participated in this study. Hospital records of 2121 children below 15 yr of age were examined retrospectively. DKA was defined as glucose > 250 mg/dL, pH < 7.30 or bicarbonate < 15 mmol/L and ketonuria. Statistical analysis was done after logarithmic transformation.
Results: 26.3% (n = 558) of all patients presented with DKA. The mean age of these patients was 7.9 yr. The frequency of DKA is higher in girls than in boys (28.9 vs. 23.8%; p = 0.0079). Those aged 0–4 yr suffered most frequently (p < 0.0001) from ketoacidosis (36.0%). The percentage of DKA in newly diagnosed cases was constant over 10 yr. 23.3% of all patients with DKA presented with an altered level of consciousness; 10.9% of these had clinical signs of coma. No deaths occurred. The proportion of ketoacidosis does not increase concurrently with the number of diabetes manifestations in winter.
Conclusion: The proportion of DKA in children with newly diagnosed diabetes mellitus is significant. In particular, children < 5 yr and girls face an increased risk. DKA may be the result of a particularly aggressive subtype of diabetes.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetic Ketoacidosis - epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>incidence registry</subject><subject>Infant</subject><subject>ketoacidosis</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sex Characteristics</subject><subject>subtype</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0Eorx-AXnFLsGOnTpZsEBtKY-Kl0CwsxxnLFxSp8SuaP-ehJbixXikOXc0OghhSmJKGD-fxpTleZRynsUJISwm7RPxcgcdbAe7256999Ch91NCqMgZ30c9yvtpmvTZAdJ3EGqlbVl767EKuHYe2mpwWM0BU1xaVUAAj2dQVTYsPLYO6w9blQ04HGHTwNcCnF5h5UqsK-usVhWeN-DBBRVs7Y7RnlGVh5PNf4Rer0Yvg-to8jC-GVxOIs1oLiKeqdwILQyhRW4KZkyuDTCWFYSqgpssSzNTatrBhqdpWZiMJrxPqAaS5CU7QmfrvfOmbm_yQc6s1-3ZykG98FJQzmiSihY83YCLYgalnDd2ppqV_NPSAhdr4NtWsPqfE9npl1PZmZWdZdnpl7_65VI-joY3bdfmo3Xe-gDLbV41n7IvmEjl2_1YDofXz4MncSvf2A_j5Yi-</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Neu, Andreas</creator><creator>Willasch, Andre</creator><creator>Ehehalt, Stefan</creator><creator>Hub, Regine</creator><creator>Ranke, Michael B.</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Ketoacidosis at onset of type 1 diabetes mellitus in children - frequency and clinical presentation</title><author>Neu, Andreas ; Willasch, Andre ; Ehehalt, Stefan ; Hub, Regine ; Ranke, Michael B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3197-48a9f7c7f01b9fb3ff9cfe338b01ab4f8858fdc13197f455dbf8124601ce029d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetic Ketoacidosis - epidemiology</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>incidence registry</topic><topic>Infant</topic><topic>ketoacidosis</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sex Characteristics</topic><topic>subtype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neu, Andreas</creatorcontrib><creatorcontrib>Willasch, Andre</creatorcontrib><creatorcontrib>Ehehalt, Stefan</creatorcontrib><creatorcontrib>Hub, Regine</creatorcontrib><creatorcontrib>Ranke, Michael B.</creatorcontrib><creatorcontrib>DIARY Group Baden-Wuerttemberg</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neu, Andreas</au><au>Willasch, Andre</au><au>Ehehalt, Stefan</au><au>Hub, Regine</au><au>Ranke, Michael B.</au><aucorp>DIARY Group Baden-Wuerttemberg</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketoacidosis at onset of type 1 diabetes mellitus in children - frequency and clinical presentation</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2003-06</date><risdate>2003</risdate><volume>4</volume><issue>2</issue><spage>77</spage><epage>81</epage><pages>77-81</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>: Background: Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden‐Wuerttemberg (BW), Germany.
Aim: Our aim was to describe the frequency and the clinical presentation of diabetic ketoacidosis (DKA) at onset of type 1 diabetes mellitus in children.
Methods: All 31 pediatric departments in BW and one diabetes center participated in this study. Hospital records of 2121 children below 15 yr of age were examined retrospectively. DKA was defined as glucose > 250 mg/dL, pH < 7.30 or bicarbonate < 15 mmol/L and ketonuria. Statistical analysis was done after logarithmic transformation.
Results: 26.3% (n = 558) of all patients presented with DKA. The mean age of these patients was 7.9 yr. The frequency of DKA is higher in girls than in boys (28.9 vs. 23.8%; p = 0.0079). Those aged 0–4 yr suffered most frequently (p < 0.0001) from ketoacidosis (36.0%). The percentage of DKA in newly diagnosed cases was constant over 10 yr. 23.3% of all patients with DKA presented with an altered level of consciousness; 10.9% of these had clinical signs of coma. No deaths occurred. The proportion of ketoacidosis does not increase concurrently with the number of diabetes manifestations in winter.
Conclusion: The proportion of DKA in children with newly diagnosed diabetes mellitus is significant. In particular, children < 5 yr and girls face an increased risk. DKA may be the result of a particularly aggressive subtype of diabetes.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14655263</pmid><doi>10.1034/j.1399-5448.2003.00007.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Age Factors Child Child, Preschool children diabetes mellitus Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetic Ketoacidosis - epidemiology Female Germany - epidemiology Humans Incidence incidence registry Infant ketoacidosis Male Retrospective Studies Severity of Illness Index Sex Characteristics subtype |
| title | Ketoacidosis at onset of type 1 diabetes mellitus in children - frequency and clinical presentation |
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