Effects of cilomilast on dendritic cell function in contact sensitivity and dendritic cell migration through skin

The phosphodiesterase 4 inhibitor cilomilast demonstrated strong inhibitory effects in a model of allergic contact dermatitis. In this study, we examined whether this inhibitory effect is at least partly due to modulation of dendritic cell function. Bone marrow-derived dendritic cells were pulsed wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2003-11, Vol.481 (2), p.271-279
Hauptverfasser:	Bäumer, Wolfgang, Tschernig, Thomas, Sülzle, Boris, Seegers, Ulrike, Lührmann, Anke, Kietzmann, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchodilator Agents - pharmacology Bronchodilator Agents - therapeutic use Carboxylic Acids Cell Movement - drug effects Cell Movement - physiology Cilomilast Cyclohexanecarboxylic Acids Dendritic cell Dendritic Cells - drug effects Dendritic Cells - physiology Dermatitis, Allergic Contact - drug therapy Dermatitis, Allergic Contact - pathology Female Matrix metalloproteinase 9 Medical sciences Mice Mice, Inbred BALB C mouse Nitriles Pharmacology. Drug treatments Phosphodiesterase 4 inhibitor Skin Skin - drug effects Skin - pathology Toluene-2,4-diisocyanate Zymography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!