Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients
Objectives: The aim of the study was to test a possible association between the Val66Met polymorphism of the brain‐derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients. Methods: Fifty‐four bipolar patients wer...
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| Veröffentlicht in: | Bipolar disorders 2003-12, Vol.5 (6), p.468-472 |
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| creator | Rybakowski, Janusz K Borkowska, Alina Czerski, Piotr M Skibińska, Maria Hauser, Joanna |
| description | Objectives: The aim of the study was to test a possible association between the Val66Met polymorphism of the brain‐derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients.
Methods: Fifty‐four bipolar patients were studied, 18 male and 36 female, aged 18–72 (mean 46 years). The number of perseverative errors (WCST‐P), non‐perseverative errors (WCST‐NP), completed corrected categories (WCST‐CC), conceptual level responses (WCST‐%CONC) and set to the first category (WCST‐1st CAT) were measured in relation to the Val66Met genotypes of BDNF.
Results: The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met genotypes did not differ on clinical factors except for the age of onset of the illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 years). The performance in all domains of WCST was significantly better in subjects with Val/Val BDNF genotype compared with Val/Met genotype.
Conclusions: The results suggest a role of BDNF in prefrontal cognitive function in bipolar illness. The tests of prefrontal cognition may be considered as endophenotypic markers in bipolar illness. |
| doi_str_mv | 10.1046/j.1399-5618.2003.00071.x |
| format | Article |
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Methods: Fifty‐four bipolar patients were studied, 18 male and 36 female, aged 18–72 (mean 46 years). The number of perseverative errors (WCST‐P), non‐perseverative errors (WCST‐NP), completed corrected categories (WCST‐CC), conceptual level responses (WCST‐%CONC) and set to the first category (WCST‐1st CAT) were measured in relation to the Val66Met genotypes of BDNF.
Results: The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met genotypes did not differ on clinical factors except for the age of onset of the illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 years). The performance in all domains of WCST was significantly better in subjects with Val/Val BDNF genotype compared with Val/Met genotype.
Conclusions: The results suggest a role of BDNF in prefrontal cognitive function in bipolar illness. The tests of prefrontal cognition may be considered as endophenotypic markers in bipolar illness.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1046/j.1399-5618.2003.00071.x</identifier><identifier>PMID: 14636373</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Aged ; bipolar disorder ; Bipolar Disorder - blood ; Bipolar Disorder - genetics ; Bipolar Disorder - psychology ; Brain-Derived Neurotrophic Factor - blood ; Brain-Derived Neurotrophic Factor - genetics ; brain-derived neurotropic factor ; Cognition ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Poland ; Polymorphism, Genetic ; Prefrontal Cortex - physiopathology ; prefrontal function ; Val66Met polymorphism ; Wisconsin Card Sorting Test</subject><ispartof>Bipolar disorders, 2003-12, Vol.5 (6), p.468-472</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4331-5cefd8ca2d009e1fe7a1b6aa7d39628ad8284da0c5ac28a6bdf27def9bbd34833</citedby><cites>FETCH-LOGICAL-c4331-5cefd8ca2d009e1fe7a1b6aa7d39628ad8284da0c5ac28a6bdf27def9bbd34833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1399-5618.2003.00071.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14636373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rybakowski, Janusz K</creatorcontrib><creatorcontrib>Borkowska, Alina</creatorcontrib><creatorcontrib>Czerski, Piotr M</creatorcontrib><creatorcontrib>Skibińska, Maria</creatorcontrib><creatorcontrib>Hauser, Joanna</creatorcontrib><title>Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objectives: The aim of the study was to test a possible association between the Val66Met polymorphism of the brain‐derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients.
Methods: Fifty‐four bipolar patients were studied, 18 male and 36 female, aged 18–72 (mean 46 years). The number of perseverative errors (WCST‐P), non‐perseverative errors (WCST‐NP), completed corrected categories (WCST‐CC), conceptual level responses (WCST‐%CONC) and set to the first category (WCST‐1st CAT) were measured in relation to the Val66Met genotypes of BDNF.
Results: The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met genotypes did not differ on clinical factors except for the age of onset of the illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 years). The performance in all domains of WCST was significantly better in subjects with Val/Val BDNF genotype compared with Val/Met genotype.
Conclusions: The results suggest a role of BDNF in prefrontal cognitive function in bipolar illness. The tests of prefrontal cognition may be considered as endophenotypic markers in bipolar illness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>bipolar disorder</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - psychology</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>brain-derived neurotropic factor</subject><subject>Cognition</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Poland</subject><subject>Polymorphism, Genetic</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>prefrontal function</subject><subject>Val66Met polymorphism</subject><subject>Wisconsin Card Sorting Test</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAURSNUREvhF5BX7JLacRInEhta6FCpGroAurRe7JfWQ2KntgdmFvw7ns6oLMvK1_I9z7ZOlhFGC0ar5mxVMN51ed2wtigp5QWlVLBi8yI7eTo4esxtypU4zl6HsKKUNSWtX2XHrGp4wwU_yf7cuHE7OT_fmzARN5B4j6T3YGyu0ZtfqInFtXfRu1RRZAAVnSd3aJGA1WRGPzg_gVVInCVAlLuzJiaQzB4H72yEkUQMkRhLejO7ETyZIRq0MbzJXg4wBnx7WE-z75efv118ya-_Lq4uPl7nquKc5bXCQbcKSk1ph2xAAaxvAITmXVO2oNuyrTRQVYNK26bXQyk0Dl3fa161nJ9m7_dzZ-8e1ukxcjJB4TiCRbcOUrCKU8bLZ4tM8LKraJuK7b6ovAsh_VTO3kzgt5JRuXMkV3KnQu5UyJ0j-ehIbhL67nDHup9Q_wMPUlLhw77w24y4_e_B8vzTVQoJz_e4CRE3Tzj4n7IRXNTydrmQy479uFncLiXnfwHiy7KQ</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Rybakowski, Janusz K</creator><creator>Borkowska, Alina</creator><creator>Czerski, Piotr M</creator><creator>Skibińska, Maria</creator><creator>Hauser, Joanna</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients</title><author>Rybakowski, Janusz K ; Borkowska, Alina ; Czerski, Piotr M ; Skibińska, Maria ; Hauser, Joanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4331-5cefd8ca2d009e1fe7a1b6aa7d39628ad8284da0c5ac28a6bdf27def9bbd34833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>bipolar disorder</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - psychology</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>brain-derived neurotropic factor</topic><topic>Cognition</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Poland</topic><topic>Polymorphism, Genetic</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>prefrontal function</topic><topic>Val66Met polymorphism</topic><topic>Wisconsin Card Sorting Test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rybakowski, Janusz K</creatorcontrib><creatorcontrib>Borkowska, Alina</creatorcontrib><creatorcontrib>Czerski, Piotr M</creatorcontrib><creatorcontrib>Skibińska, Maria</creatorcontrib><creatorcontrib>Hauser, Joanna</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rybakowski, Janusz K</au><au>Borkowska, Alina</au><au>Czerski, Piotr M</au><au>Skibińska, Maria</au><au>Hauser, Joanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2003-12</date><risdate>2003</risdate><volume>5</volume><issue>6</issue><spage>468</spage><epage>472</epage><pages>468-472</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><abstract>Objectives: The aim of the study was to test a possible association between the Val66Met polymorphism of the brain‐derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients.
Methods: Fifty‐four bipolar patients were studied, 18 male and 36 female, aged 18–72 (mean 46 years). The number of perseverative errors (WCST‐P), non‐perseverative errors (WCST‐NP), completed corrected categories (WCST‐CC), conceptual level responses (WCST‐%CONC) and set to the first category (WCST‐1st CAT) were measured in relation to the Val66Met genotypes of BDNF.
Results: The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met genotypes did not differ on clinical factors except for the age of onset of the illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 years). The performance in all domains of WCST was significantly better in subjects with Val/Val BDNF genotype compared with Val/Met genotype.
Conclusions: The results suggest a role of BDNF in prefrontal cognitive function in bipolar illness. The tests of prefrontal cognition may be considered as endophenotypic markers in bipolar illness.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14636373</pmid><doi>10.1046/j.1399-5618.2003.00071.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged bipolar disorder Bipolar Disorder - blood Bipolar Disorder - genetics Bipolar Disorder - psychology Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - genetics brain-derived neurotropic factor Cognition Female Genotype Humans Male Middle Aged Neuropsychological Tests Poland Polymorphism, Genetic Prefrontal Cortex - physiopathology prefrontal function Val66Met polymorphism Wisconsin Card Sorting Test |
| title | Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients |
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