Peroxynitrite reactivity with amino acids and proteins

Peroxynitrite, the product of the fast reaction between nitric oxide (•NO) and superoxide O₂•⁻radicals, is an oxidizing and nitrating agent which is able to traverse biological membranes. The reaction of peroxynitrite with proteins occurs through three possible pathways. First, peroxynitrite reacts...

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Veröffentlicht in:	Amino acids 2003-12, Vol.25 (3-4), p.295-311
Hauptverfasser:	Alvarez, B, Radi, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - chemistry Amino Acids - metabolism Animals Antioxidants - chemistry Antioxidants - metabolism Carbon dioxide cysteine Cytosol - metabolism Free Radicals - metabolism Humans methionine Models, Chemical Molecular Structure Nitration Nitric oxide Nitric Oxide - metabolism Nitrogen dioxide Oxidation-Reduction Pathways Peroxynitrous Acid - chemistry Peroxynitrous Acid - metabolism Proteins Proteins - chemistry Proteins - metabolism Radicals Residues superoxide anion Superoxides - metabolism tryptophan Tyrosine
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