Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide

Nitric oxide (NO) and superoxide anions (·O− 2 ), which are known to be generated by inflammatory cells under certain pathological conditions, may be cytotoxic to the endothelial cells (ECs) due to peroxynitrite formation. We reported previously that certain lipophilic dihydropyridine (DHP) Ca-block...

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Veröffentlicht in:	Pharmacological research 2002-01, Vol.45 (1), p.27-33
Hauptverfasser:	Tong Mak, I., Zhang, Jingyun, Weglicki, William B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - metabolism Cattle Cell Survival - drug effects Cells, Cultured Chromans - pharmacology Dose-Response Relationship, Drug Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Glutathione - metabolism Lipid Peroxidation - drug effects Molsidomine - analogs & derivatives Molsidomine - pharmacology Nicardipine - pharmacology Nifedipine - pharmacology Nisoldipine - pharmacology Nitric Oxide - pharmacology nitric oxide, SIN-1, peroxynitrite, endothelial cell injury, DHP Ca-blockers Oxidative Stress - drug effects Peroxynitrous Acid - pharmacology Superoxides - pharmacology Thiobarbituric Acid Reactive Substances - metabolism
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