The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells
The antiproliferative effects of two commercial preparations of conjugated linoleic acid (CLA) and their constituent isomers, cis-9, trans-11 (c9,t11)-CLA, c9,c11-CLA, and t10,c12-CLA, were determined in vitro using human colorectal (HT-29, MIP-101) and prostate (PC-3) carcinoma cells adapted to ser...
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| Veröffentlicht in: | Cancer letters 2002-03, Vol.177 (2), p.163-172 |
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| creator | Palombo, John D Ganguly, Aniruddha Bistrian, Bruce R Menard, Michael P |
| description | The antiproliferative effects of two commercial preparations of conjugated linoleic acid (CLA) and their constituent isomers,
cis-9,
trans-11 (c9,t11)-CLA, c9,c11-CLA, and t10,c12-CLA, were determined in vitro using human colorectal (HT-29, MIP-101) and prostate (PC-3) carcinoma cells adapted to serum-free medium. The antiproliferative effects of the preparations were dependent upon the type and concentration of CLA isomer present. The t10,c12-CLA isomer exhibited the greatest potency against colorectal cancer proliferation, and the c9,t11 and t10,c12 isomers were moderately effective against prostate cancer. The t10,c12 isomer induced caspase-dependent apoptosis in MIP-101 and PC-3 cells. The results are the first to demonstrate that physiologic levels of two CLA preparations, their constituent isomers, and the c9,t11-CLA elongation product, c11,t13-conjugated eicosadienoic acid, induce dose-dependent inhibitory effects on cancer proliferation in vitro. Novel CLA preparations may prove effective as chemopreventive supplements for individuals at risk of or diagnosed with colorectal or prostate cancer. |
| doi_str_mv | 10.1016/S0304-3835(01)00796-0 |
| format | Article |
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cis-9,
trans-11 (c9,t11)-CLA, c9,c11-CLA, and t10,c12-CLA, were determined in vitro using human colorectal (HT-29, MIP-101) and prostate (PC-3) carcinoma cells adapted to serum-free medium. The antiproliferative effects of the preparations were dependent upon the type and concentration of CLA isomer present. The t10,c12-CLA isomer exhibited the greatest potency against colorectal cancer proliferation, and the c9,t11 and t10,c12 isomers were moderately effective against prostate cancer. The t10,c12 isomer induced caspase-dependent apoptosis in MIP-101 and PC-3 cells. The results are the first to demonstrate that physiologic levels of two CLA preparations, their constituent isomers, and the c9,t11-CLA elongation product, c11,t13-conjugated eicosadienoic acid, induce dose-dependent inhibitory effects on cancer proliferation in vitro. Novel CLA preparations may prove effective as chemopreventive supplements for individuals at risk of or diagnosed with colorectal or prostate cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(01)00796-0</identifier><identifier>PMID: 11825663</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Cancer proliferation ; Carcinogenesis, carcinogens and anticarcinogens ; Caspase ; Cell Division - drug effects ; Cell growth ; Chemical agents ; Colorectal ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Conjugated linoleic acid ; Fatty acids ; Humans ; Isomer ; Isomerism ; Linoleic Acids - pharmacology ; Linoleic Acids - therapeutic use ; Male ; Medical sciences ; Oils & fats ; Prostate ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - pathology ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Cancer letters, 2002-03, Vol.177 (2), p.163-172</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Elsevier Limited Mar 28, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5a5dce0c62f69499a5bf5daba091415f6af886d8d06ff5298f5f86bcfd44f6a83</citedby><cites>FETCH-LOGICAL-c471t-5a5dce0c62f69499a5bf5daba091415f6af886d8d06ff5298f5f86bcfd44f6a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383501007960$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13551487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11825663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palombo, John D</creatorcontrib><creatorcontrib>Ganguly, Aniruddha</creatorcontrib><creatorcontrib>Bistrian, Bruce R</creatorcontrib><creatorcontrib>Menard, Michael P</creatorcontrib><title>The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The antiproliferative effects of two commercial preparations of conjugated linoleic acid (CLA) and their constituent isomers,
cis-9,
trans-11 (c9,t11)-CLA, c9,c11-CLA, and t10,c12-CLA, were determined in vitro using human colorectal (HT-29, MIP-101) and prostate (PC-3) carcinoma cells adapted to serum-free medium. The antiproliferative effects of the preparations were dependent upon the type and concentration of CLA isomer present. The t10,c12-CLA isomer exhibited the greatest potency against colorectal cancer proliferation, and the c9,t11 and t10,c12 isomers were moderately effective against prostate cancer. The t10,c12 isomer induced caspase-dependent apoptosis in MIP-101 and PC-3 cells. The results are the first to demonstrate that physiologic levels of two CLA preparations, their constituent isomers, and the c9,t11-CLA elongation product, c11,t13-conjugated eicosadienoic acid, induce dose-dependent inhibitory effects on cancer proliferation in vitro. Novel CLA preparations may prove effective as chemopreventive supplements for individuals at risk of or diagnosed with colorectal or prostate cancer.</description><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cancer proliferation</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Caspase</subject><subject>Cell Division - drug effects</subject><subject>Cell growth</subject><subject>Chemical agents</subject><subject>Colorectal</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Conjugated linoleic acid</subject><subject>Fatty acids</subject><subject>Humans</subject><subject>Isomer</subject><subject>Isomerism</subject><subject>Linoleic Acids - pharmacology</subject><subject>Linoleic Acids - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oils & fats</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFjEUhYMo9m31JygBsehi9GYmyWRWIsUvKLiwrkMmH21eMpOazBT6C_zb3vcDC25cZXGee-_JOYS8YPCOAZPvf0AHvOlUJ94AewvQD7KBR2TDVN82_aDgMdn8RU7Iaa1bABC8F0_JCWOqFVJ2G_L76sZTMy_xtuQUgy9miXee-hC8XSrNgY4xp3wdrUnpnhq7l2PNky972eZ5u16bxTua4pyTjxap6Gie6c06mRmJlAtuMwkPOYqH6oJXLLVmtr5Q61Oqz8iTYFL1z4_vGfn5-dPVxdfm8vuXbxcfLxvLe7Y0wghnPVjZBjnwYTBiDMKZ0cDAOBNBmqCUdMqBDEG0gwoiKDna4DhHUXVn5PywF238Wn1d9BTrzoGZfV6r7hlvexg6BF_9A27zWmb0ppkA0UnolURKHCiLv6rFB31b4mTKvWagdz3pfU96V4IGpvc9acC5l8ft6zh59zB1LAaB10fAVIw-FMwq1geuE4Jx1SP34cB5DO0u-qKrjR5zdXGXuXY5_sfKH1eDsek</recordid><startdate>20020328</startdate><enddate>20020328</enddate><creator>Palombo, John D</creator><creator>Ganguly, Aniruddha</creator><creator>Bistrian, Bruce R</creator><creator>Menard, Michael P</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020328</creationdate><title>The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells</title><author>Palombo, John D ; Ganguly, Aniruddha ; Bistrian, Bruce R ; Menard, Michael P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5a5dce0c62f69499a5bf5daba091415f6af886d8d06ff5298f5f86bcfd44f6a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cancer proliferation</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Caspase</topic><topic>Cell Division - drug effects</topic><topic>Cell growth</topic><topic>Chemical agents</topic><topic>Colorectal</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Conjugated linoleic acid</topic><topic>Fatty acids</topic><topic>Humans</topic><topic>Isomer</topic><topic>Isomerism</topic><topic>Linoleic Acids - pharmacology</topic><topic>Linoleic Acids - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oils & fats</topic><topic>Prostate</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palombo, John D</creatorcontrib><creatorcontrib>Ganguly, Aniruddha</creatorcontrib><creatorcontrib>Bistrian, Bruce R</creatorcontrib><creatorcontrib>Menard, Michael P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palombo, John D</au><au>Ganguly, Aniruddha</au><au>Bistrian, Bruce R</au><au>Menard, Michael P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2002-03-28</date><risdate>2002</risdate><volume>177</volume><issue>2</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The antiproliferative effects of two commercial preparations of conjugated linoleic acid (CLA) and their constituent isomers,
cis-9,
trans-11 (c9,t11)-CLA, c9,c11-CLA, and t10,c12-CLA, were determined in vitro using human colorectal (HT-29, MIP-101) and prostate (PC-3) carcinoma cells adapted to serum-free medium. The antiproliferative effects of the preparations were dependent upon the type and concentration of CLA isomer present. The t10,c12-CLA isomer exhibited the greatest potency against colorectal cancer proliferation, and the c9,t11 and t10,c12 isomers were moderately effective against prostate cancer. The t10,c12 isomer induced caspase-dependent apoptosis in MIP-101 and PC-3 cells. The results are the first to demonstrate that physiologic levels of two CLA preparations, their constituent isomers, and the c9,t11-CLA elongation product, c11,t13-conjugated eicosadienoic acid, induce dose-dependent inhibitory effects on cancer proliferation in vitro. Novel CLA preparations may prove effective as chemopreventive supplements for individuals at risk of or diagnosed with colorectal or prostate cancer.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11825663</pmid><doi>10.1016/S0304-3835(01)00796-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | Cancer letters, 2002-03, Vol.177 (2), p.163-172 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apoptosis Apoptosis - drug effects Biological and medical sciences Cancer proliferation Carcinogenesis, carcinogens and anticarcinogens Caspase Cell Division - drug effects Cell growth Chemical agents Colorectal Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Conjugated linoleic acid Fatty acids Humans Isomer Isomerism Linoleic Acids - pharmacology Linoleic Acids - therapeutic use Male Medical sciences Oils & fats Prostate Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Tumor Cells, Cultured Tumors |
| title | The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells |
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