Fluid Flow Induction of Cyclo‐Oxygenase 2 Gene Expression in Osteoblasts Is Dependent on an Extracellular Signal‐Regulated Kinase Signaling Pathway

Mechanical loading of bone may be transmitted to osteocytes and osteoblasts via shear stresses at cell surfaces generated by the flow of interstitial fluid. The stimulated production of prostaglandins, which mediates some effects of mechanical loading on bone, is dependent on inducible cyclo‐oxygena...

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Veröffentlicht in:	Journal of bone and mineral research 2002-02, Vol.17 (2), p.266-274
Hauptverfasser:	Wadhwa, Sunil, Godwin, Stephen L., Peterson, Donald R., Epstein, Mary A., Raisz, Lawrence G., Pilbeam, Carol C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Butadienes - pharmacology Cells, Cultured Cyclooxygenase 2 Enzyme Inhibitors - pharmacology Extracellular Matrix - metabolism extracellular signal-regulated kinase Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology gene expression regulation Isoenzymes - genetics Isoenzymes - metabolism Luciferases - genetics Luciferases - metabolism mechanical stress Mice Mice, Transgenic Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Nitriles - pharmacology Osteoblasts - physiology Phosphorylation Promoter Regions, Genetic Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism prostaglandins prostaglandin‐endoperoxide synthase RNA, Messenger - metabolism Signal Transduction Skeleton and joints Skull - cytology Transcription, Genetic Vertebrates: osteoarticular system, musculoskeletal system
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