Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats
Rat models of immobilization-induced osteopenia are characterized by uncoupling of bone metabolism, i.e., increased bone resorption and decreased bone formation in trabecular bone. Using such a rat model, the efficacy of osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin, a novel secreted p...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2002, Vol.20 (1), p.14-20 |
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| creator | MOCHIZUKI, Shin-Ichi FUJISE, Nobuaki HIGASHIO, Kanji TSUDA, Eisuke |
| description | Rat models of immobilization-induced osteopenia are characterized by uncoupling of bone metabolism, i.e., increased bone resorption and decreased bone formation in trabecular bone. Using such a rat model, the efficacy of osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin, a novel secreted protein that inhibits osteoclastogenesis, in reducing bone loss was investigated. Male Fischer rats were neurectomized and injected intramuscularly with either OCIF (0.2, 1.0, or 5.0 mg/kg body weight) or vehicle once daily for 7 days. On the eighth day after sciatic neurectomy, significant bone loss was observed in the vehicle-injected rats. OCIF ameliorated the decrease in bone mineral density (BMD) of both the proximal and distal femur in a dose-dependent manner. OCIF also ameliorated the decrease in bone strength of the femoral neck at the highest dose. A high correlation (r = 0.805) was detected between the BMD of the distal femur and the bone strength of the femoral neck. When OCIF was administered intermittently to the immobilized rats twice weekly (on days 1 and 4) after immobilization, it also ameliorated the decrease in BMD of the distal femur. These results suggest that OCIF has therapeutic potential for the treatment of immobilization-induced osteopenia. |
| doi_str_mv | 10.1007/s774-002-8441-x |
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Using such a rat model, the efficacy of osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin, a novel secreted protein that inhibits osteoclastogenesis, in reducing bone loss was investigated. Male Fischer rats were neurectomized and injected intramuscularly with either OCIF (0.2, 1.0, or 5.0 mg/kg body weight) or vehicle once daily for 7 days. On the eighth day after sciatic neurectomy, significant bone loss was observed in the vehicle-injected rats. OCIF ameliorated the decrease in bone mineral density (BMD) of both the proximal and distal femur in a dose-dependent manner. OCIF also ameliorated the decrease in bone strength of the femoral neck at the highest dose. A high correlation (r = 0.805) was detected between the BMD of the distal femur and the bone strength of the femoral neck. When OCIF was administered intermittently to the immobilized rats twice weekly (on days 1 and 4) after immobilization, it also ameliorated the decrease in BMD of the distal femur. These results suggest that OCIF has therapeutic potential for the treatment of immobilization-induced osteopenia.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s774-002-8441-x</identifier><identifier>PMID: 11810411</identifier><language>eng</language><publisher>Tokyo: Springer</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Bone density ; Bone Density - drug effects ; Bone Resorption - prevention & control ; Bones ; Dose-Response Relationship, Drug ; Femur - drug effects ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - administration & dosage ; Glycoproteins - therapeutic use ; Injections, Intramuscular ; Male ; Older people ; Osteoporosis ; Osteoprotegerin ; Rats ; Rats, Inbred F344 ; Receptors, Cytoplasmic and Nuclear - administration & dosage ; Receptors, Cytoplasmic and Nuclear - therapeutic use ; Receptors, Tumor Necrosis Factor ; Restraint, Physical ; Rodents ; Sciatic Nerve - physiology ; Skeleton and joints ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of bone and mineral metabolism, 2002, Vol.20 (1), p.14-20</ispartof><rights>2002 INIST-CNRS</rights><rights>Springer-Verlag Tokyo 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-5b027374d27779349e64a933699e7f1225a62bf84135595169ac3beaaf52bdd63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14123525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11810411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOCHIZUKI, Shin-Ichi</creatorcontrib><creatorcontrib>FUJISE, Nobuaki</creatorcontrib><creatorcontrib>HIGASHIO, Kanji</creatorcontrib><creatorcontrib>TSUDA, Eisuke</creatorcontrib><title>Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><description>Rat models of immobilization-induced osteopenia are characterized by uncoupling of bone metabolism, i.e., increased bone resorption and decreased bone formation in trabecular bone. Using such a rat model, the efficacy of osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin, a novel secreted protein that inhibits osteoclastogenesis, in reducing bone loss was investigated. Male Fischer rats were neurectomized and injected intramuscularly with either OCIF (0.2, 1.0, or 5.0 mg/kg body weight) or vehicle once daily for 7 days. On the eighth day after sciatic neurectomy, significant bone loss was observed in the vehicle-injected rats. OCIF ameliorated the decrease in bone mineral density (BMD) of both the proximal and distal femur in a dose-dependent manner. OCIF also ameliorated the decrease in bone strength of the femoral neck at the highest dose. A high correlation (r = 0.805) was detected between the BMD of the distal femur and the bone strength of the femoral neck. When OCIF was administered intermittently to the immobilized rats twice weekly (on days 1 and 4) after immobilization, it also ameliorated the decrease in BMD of the distal femur. These results suggest that OCIF has therapeutic potential for the treatment of immobilization-induced osteopenia.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone Resorption - prevention & control</subject><subject>Bones</subject><subject>Dose-Response Relationship, Drug</subject><subject>Femur - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycoproteins - administration & dosage</subject><subject>Glycoproteins - therapeutic use</subject><subject>Injections, Intramuscular</subject><subject>Male</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Osteoprotegerin</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Receptors, Cytoplasmic and Nuclear - administration & dosage</subject><subject>Receptors, Cytoplasmic and Nuclear - therapeutic use</subject><subject>Receptors, Tumor Necrosis Factor</subject><subject>Restraint, Physical</subject><subject>Rodents</subject><subject>Sciatic Nerve - physiology</subject><subject>Skeleton and joints</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU1r3DAQhkVpaTZJz70VQ2lu7mr0YdnHEpq0EMilOQvZHu8q2FKq0UI2v6I_uVp2IdBLL5rDPPOil4exj8C_AudmTcaomnNRt0pB_fyGrUBJXeuGq7dsxTtQdWtMd8bOiR45B6MNvGdnAC1wBbBif-4pYxxmRzluMCB5qnzY-t7nmPbV5IYy1_EAPaWYcYPJh8otOPuYXEaq8harEYeEjrCcVn3M2_IErBYfMLm5bAP5vK9cGI8LygnDpmAF98sSez_7FxyrEkiX7N3kZsIPp3nBHm6-_7r-Ud_d3_68_nZXD6VgrnXPhZFGjcKUflJ12CjXSdl0HZoJhNCuEf3UKpBadxqazg2yR-cmLfpxbOQFuzrmllq_d0jZLp4GnGcXMO7IGlCiaYT6LwitEZ1odAE__wM-xl0KpYQFKN-QUNIKtT5SQ4pECSf7lPzi0t4Ctwen9uDUFqf24NQ-l4tPp9xdv-D4yp8kFuDLCXA0uHlKLgyeXjkFQmqh5V8BO6vj</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>MOCHIZUKI, Shin-Ichi</creator><creator>FUJISE, Nobuaki</creator><creator>HIGASHIO, Kanji</creator><creator>TSUDA, Eisuke</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats</title><author>MOCHIZUKI, Shin-Ichi ; FUJISE, Nobuaki ; HIGASHIO, Kanji ; TSUDA, Eisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-5b027374d27779349e64a933699e7f1225a62bf84135595169ac3beaaf52bdd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Bone density</topic><topic>Bone Density - drug effects</topic><topic>Bone Resorption - prevention & control</topic><topic>Bones</topic><topic>Dose-Response Relationship, Drug</topic><topic>Femur - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycoproteins - administration & dosage</topic><topic>Glycoproteins - therapeutic use</topic><topic>Injections, Intramuscular</topic><topic>Male</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Osteoprotegerin</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Receptors, Cytoplasmic and Nuclear - administration & dosage</topic><topic>Receptors, Cytoplasmic and Nuclear - therapeutic use</topic><topic>Receptors, Tumor Necrosis Factor</topic><topic>Restraint, Physical</topic><topic>Rodents</topic><topic>Sciatic Nerve - physiology</topic><topic>Skeleton and joints</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOCHIZUKI, Shin-Ichi</creatorcontrib><creatorcontrib>FUJISE, Nobuaki</creatorcontrib><creatorcontrib>HIGASHIO, Kanji</creatorcontrib><creatorcontrib>TSUDA, Eisuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOCHIZUKI, Shin-Ichi</au><au>FUJISE, Nobuaki</au><au>HIGASHIO, Kanji</au><au>TSUDA, Eisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><addtitle>J Bone Miner Metab</addtitle><date>2002</date><risdate>2002</risdate><volume>20</volume><issue>1</issue><spage>14</spage><epage>20</epage><pages>14-20</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Rat models of immobilization-induced osteopenia are characterized by uncoupling of bone metabolism, i.e., increased bone resorption and decreased bone formation in trabecular bone. Using such a rat model, the efficacy of osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin, a novel secreted protein that inhibits osteoclastogenesis, in reducing bone loss was investigated. Male Fischer rats were neurectomized and injected intramuscularly with either OCIF (0.2, 1.0, or 5.0 mg/kg body weight) or vehicle once daily for 7 days. On the eighth day after sciatic neurectomy, significant bone loss was observed in the vehicle-injected rats. OCIF ameliorated the decrease in bone mineral density (BMD) of both the proximal and distal femur in a dose-dependent manner. OCIF also ameliorated the decrease in bone strength of the femoral neck at the highest dose. A high correlation (r = 0.805) was detected between the BMD of the distal femur and the bone strength of the femoral neck. When OCIF was administered intermittently to the immobilized rats twice weekly (on days 1 and 4) after immobilization, it also ameliorated the decrease in BMD of the distal femur. These results suggest that OCIF has therapeutic potential for the treatment of immobilization-induced osteopenia.</abstract><cop>Tokyo</cop><pub>Springer</pub><pmid>11810411</pmid><doi>10.1007/s774-002-8441-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Body Weight Bone density Bone Density - drug effects Bone Resorption - prevention & control Bones Dose-Response Relationship, Drug Femur - drug effects Fundamental and applied biological sciences. Psychology Glycoproteins - administration & dosage Glycoproteins - therapeutic use Injections, Intramuscular Male Older people Osteoporosis Osteoprotegerin Rats Rats, Inbred F344 Receptors, Cytoplasmic and Nuclear - administration & dosage Receptors, Cytoplasmic and Nuclear - therapeutic use Receptors, Tumor Necrosis Factor Restraint, Physical Rodents Sciatic Nerve - physiology Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system |
| title | Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats |
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