Fenton-Dependent Damage to Carbohydrates: Free Radical Scavenging Activity of Some Simple Sugars
The antioxidant properties of simple carbohydrates were studied in a chemical system. Hydroxyl radicals generated by a Fenton reaction induce damage on simple carbohydrates with a consequent free radical scavenging activity. Carbohydrate activities were measured by different methods as spin-trapping...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2003-12, Vol.51 (25), p.7418-7425 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 51 |
| creator | Morelli, Roberto Russo-Volpe, Samantha Bruno, Novella Lo Scalzo, Roberto |
| description | The antioxidant properties of simple carbohydrates were studied in a chemical system. Hydroxyl radicals generated by a Fenton reaction induce damage on simple carbohydrates with a consequent free radical scavenging activity. Carbohydrate activities were measured by different methods as spin-trapping of hydroxyl radical and electron paramagnetic resonance detection and 1,1-diphenyl-2-picrylhydrazyl quenching. Carbohydrate damage was evaluated in a Fenton system by measuring the reactive substances to thiobarbituric acid, by their decreased detection with an HPLC test, and by a gas chromatographic determination of formic acid from sugar oxidation. Different intensities of damage and scavenging were found according to molecular structure, and some hyphotheses on the carbohydrate action against free radicals were attempted. The assayed disaccharides were shown to be more active toward and less damaged by hydroxyl radical than monosaccharides. Keywords: Simple carbohydrates; antioxidant properties; hydroxyl radical; free radical scavenging activity |
| doi_str_mv | 10.1021/jf030172q |
| format | Article |
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Hydroxyl radicals generated by a Fenton reaction induce damage on simple carbohydrates with a consequent free radical scavenging activity. Carbohydrate activities were measured by different methods as spin-trapping of hydroxyl radical and electron paramagnetic resonance detection and 1,1-diphenyl-2-picrylhydrazyl quenching. Carbohydrate damage was evaluated in a Fenton system by measuring the reactive substances to thiobarbituric acid, by their decreased detection with an HPLC test, and by a gas chromatographic determination of formic acid from sugar oxidation. Different intensities of damage and scavenging were found according to molecular structure, and some hyphotheses on the carbohydrate action against free radicals were attempted. The assayed disaccharides were shown to be more active toward and less damaged by hydroxyl radical than monosaccharides. 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Agric. Food Chem</addtitle><description>The antioxidant properties of simple carbohydrates were studied in a chemical system. Hydroxyl radicals generated by a Fenton reaction induce damage on simple carbohydrates with a consequent free radical scavenging activity. Carbohydrate activities were measured by different methods as spin-trapping of hydroxyl radical and electron paramagnetic resonance detection and 1,1-diphenyl-2-picrylhydrazyl quenching. Carbohydrate damage was evaluated in a Fenton system by measuring the reactive substances to thiobarbituric acid, by their decreased detection with an HPLC test, and by a gas chromatographic determination of formic acid from sugar oxidation. Different intensities of damage and scavenging were found according to molecular structure, and some hyphotheses on the carbohydrate action against free radicals were attempted. The assayed disaccharides were shown to be more active toward and less damaged by hydroxyl radical than monosaccharides. Keywords: Simple carbohydrates; antioxidant properties; hydroxyl radical; free radical scavenging activity</description><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds</subject><subject>Carbohydrates - chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Disaccharides - chemistry</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Formates - chemistry</subject><subject>Free Radical Scavengers - chemistry</subject><subject>General pharmacology</subject><subject>Hydrogen Peroxide - chemistry</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Hydroxyl Radical - chemistry</subject><subject>Iron - chemistry</subject><subject>Iron - pharmacology</subject><subject>Medical sciences</subject><subject>Monosaccharides - chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Picrates - chemistry</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morelli, Roberto</creatorcontrib><creatorcontrib>Russo-Volpe, Samantha</creatorcontrib><creatorcontrib>Bruno, Novella</creatorcontrib><creatorcontrib>Lo Scalzo, Roberto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morelli, Roberto</au><au>Russo-Volpe, Samantha</au><au>Bruno, Novella</au><au>Lo Scalzo, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fenton-Dependent Damage to Carbohydrates: Free Radical Scavenging Activity of Some Simple Sugars</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2003-12-03</date><risdate>2003</risdate><volume>51</volume><issue>25</issue><spage>7418</spage><epage>7425</epage><pages>7418-7425</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>The antioxidant properties of simple carbohydrates were studied in a chemical system. Hydroxyl radicals generated by a Fenton reaction induce damage on simple carbohydrates with a consequent free radical scavenging activity. Carbohydrate activities were measured by different methods as spin-trapping of hydroxyl radical and electron paramagnetic resonance detection and 1,1-diphenyl-2-picrylhydrazyl quenching. Carbohydrate damage was evaluated in a Fenton system by measuring the reactive substances to thiobarbituric acid, by their decreased detection with an HPLC test, and by a gas chromatographic determination of formic acid from sugar oxidation. 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| ispartof | Journal of agricultural and food chemistry, 2003-12, Vol.51 (25), p.7418-7425 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences Biphenyl Compounds Carbohydrates - chemistry Chromatography, High Pressure Liquid Disaccharides - chemistry Electron Spin Resonance Spectroscopy Formates - chemistry Free Radical Scavengers - chemistry General pharmacology Hydrogen Peroxide - chemistry Hydrogen Peroxide - pharmacology Hydroxyl Radical - chemistry Iron - chemistry Iron - pharmacology Medical sciences Monosaccharides - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Picrates - chemistry Thiobarbituric Acid Reactive Substances - analysis |
| title | Fenton-Dependent Damage to Carbohydrates: Free Radical Scavenging Activity of Some Simple Sugars |
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