A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions

Human chitotriosidase (Chit) is a member of the chitinase family and it is synthesized by activated macrophages. Recently, a genetic polymorphism was found to be responsible for the common deficiency in Chit activity, frequently encountered in different populations. We analyzed the Chit gene in some...

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Veröffentlicht in:	Genes and immunity 2003-12, Vol.4 (8), p.570-574
Hauptverfasser:	Malaguarnera, L, Simporè, J, Prodi, D A, Angius, A, Sassu, A, Persico, I, Barone, R, Musumeci, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Benin Biological and medical sciences Biomedical and Life Sciences Biomedicine Burkina Faso Cancer Research Child Chitin Chitinase chitotriosidase Electrophoresis Environment Environmental conditions Environmental impact analysis Enzymatic analysis Epidemiology Female Fluorometry full-paper Fundamental and applied biological sciences. Psychology Gene Expression Gene Frequency Gene polymorphism Genes. Genome Genetic Carrier Screening Genetics Health aspects Heterozygotes Hexosaminidases - genetics Human Genetics Humans Immunology Intestinal parasites Italy Macrophages Malaria Malaria - genetics Male Microbiology Minority & ethnic groups Molecular and cellular biology Molecular genetics Mutation Mutation - genetics Parasitic diseases Plasmodium falciparum Polymorphism Polymorphism, Genetic Social interactions Virology
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