Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases
Numerous studies have demonstrated that the levels of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H 2, and of prostaglandins are higher in various tumors and cells during inflammation than in normal tissues. The aim of the present study was to...
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| Veröffentlicht in: | Breast (Edinburgh) 2003-02, Vol.12 (1), p.51-57 |
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| creator | Sučić, M Boban, D Marković-Glamočak, M Jakić-Razumović, J Vrbanec, D Ries, S Gjadrov-Kuveždić, K Čobanov, A.M Podolski, P Martinović, I Erak, V Budišić, Z Ivrlač, R Unušić, J |
| description | Numerous studies have demonstrated that the levels of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H
2, and of prostaglandins are higher in various tumors and cells during inflammation than in normal tissues. The aim of the present study was to analyze whether COX-2 isoform expression was noticeably higher in fine-needle aspirates (FNA) from breast carcinoma than in FNA from fibroadenoma and fibrocystic breast tissue. COX-2 expression was detected by immunocytochemical (IC) staining and was analyzed by microscopic scoring and computer gray-scale analysis. Evaluation of COX-2 IC positivity in FNA from three groups of patients (nine with breast carcinoma, nine with fibroadenoma, eight with fibrocystic breasts) revealed high COX-2 IC positivity in the majority of patients with breast carcinoma and low or absent COX-2 IC positivity in patients with fibrocystic breast changes. In addition, low or medium COX-2 IC positivity was found in the majority of patients with fibroadenoma, only three of these patients having high COX-2 IC positivity. |
| doi_str_mv | 10.1016/S0960-9776(02)00281-3 |
| format | Article |
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2, and of prostaglandins are higher in various tumors and cells during inflammation than in normal tissues. The aim of the present study was to analyze whether COX-2 isoform expression was noticeably higher in fine-needle aspirates (FNA) from breast carcinoma than in FNA from fibroadenoma and fibrocystic breast tissue. COX-2 expression was detected by immunocytochemical (IC) staining and was analyzed by microscopic scoring and computer gray-scale analysis. Evaluation of COX-2 IC positivity in FNA from three groups of patients (nine with breast carcinoma, nine with fibroadenoma, eight with fibrocystic breasts) revealed high COX-2 IC positivity in the majority of patients with breast carcinoma and low or absent COX-2 IC positivity in patients with fibrocystic breast changes. In addition, low or medium COX-2 IC positivity was found in the majority of patients with fibroadenoma, only three of these patients having high COX-2 IC positivity.</description><identifier>ISSN: 0960-9776</identifier><identifier>EISSN: 1532-3080</identifier><identifier>DOI: 10.1016/S0960-9776(02)00281-3</identifier><identifier>PMID: 14659355</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Biopsy, Fine-Needle ; breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cyclooxygenase 2 ; cytooxygenase ; Female ; Fibroadenoma - metabolism ; Fibroadenoma - pathology ; Fibrocystic Breast Disease - metabolism ; Fibrocystic Breast Disease - pathology ; Humans ; Isoenzymes - biosynthesis ; Membrane Proteins ; Middle Aged ; Prostaglandin-Endoperoxide Synthases - biosynthesis</subject><ispartof>Breast (Edinburgh), 2003-02, Vol.12 (1), p.51-57</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-8440d014eacc9c89bac407ccfc91b56148d83a4f5a36cd548024ebb6cd0057f23</citedby><cites>FETCH-LOGICAL-c408t-8440d014eacc9c89bac407ccfc91b56148d83a4f5a36cd548024ebb6cd0057f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-9776(02)00281-3$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14659355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sučić, M</creatorcontrib><creatorcontrib>Boban, D</creatorcontrib><creatorcontrib>Marković-Glamočak, M</creatorcontrib><creatorcontrib>Jakić-Razumović, J</creatorcontrib><creatorcontrib>Vrbanec, D</creatorcontrib><creatorcontrib>Ries, S</creatorcontrib><creatorcontrib>Gjadrov-Kuveždić, K</creatorcontrib><creatorcontrib>Čobanov, A.M</creatorcontrib><creatorcontrib>Podolski, P</creatorcontrib><creatorcontrib>Martinović, I</creatorcontrib><creatorcontrib>Erak, V</creatorcontrib><creatorcontrib>Budišić, Z</creatorcontrib><creatorcontrib>Ivrlač, R</creatorcontrib><creatorcontrib>Unušić, J</creatorcontrib><title>Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases</title><title>Breast (Edinburgh)</title><addtitle>Breast</addtitle><description>Numerous studies have demonstrated that the levels of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H
2, and of prostaglandins are higher in various tumors and cells during inflammation than in normal tissues. The aim of the present study was to analyze whether COX-2 isoform expression was noticeably higher in fine-needle aspirates (FNA) from breast carcinoma than in FNA from fibroadenoma and fibrocystic breast tissue. COX-2 expression was detected by immunocytochemical (IC) staining and was analyzed by microscopic scoring and computer gray-scale analysis. Evaluation of COX-2 IC positivity in FNA from three groups of patients (nine with breast carcinoma, nine with fibroadenoma, eight with fibrocystic breasts) revealed high COX-2 IC positivity in the majority of patients with breast carcinoma and low or absent COX-2 IC positivity in patients with fibrocystic breast changes. In addition, low or medium COX-2 IC positivity was found in the majority of patients with fibroadenoma, only three of these patients having high COX-2 IC positivity.</description><subject>Adult</subject><subject>Biopsy, Fine-Needle</subject><subject>breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cyclooxygenase 2</subject><subject>cytooxygenase</subject><subject>Female</subject><subject>Fibroadenoma - metabolism</subject><subject>Fibroadenoma - pathology</subject><subject>Fibrocystic Breast Disease - metabolism</subject><subject>Fibrocystic Breast Disease - pathology</subject><subject>Humans</subject><subject>Isoenzymes - biosynthesis</subject><subject>Membrane Proteins</subject><subject>Middle Aged</subject><subject>Prostaglandin-Endoperoxide Synthases - biosynthesis</subject><issn>0960-9776</issn><issn>1532-3080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vFDEMQCNERZfCTwDlhOAwxfmayZxQVRWoVKkH4BxlEk8JmkmWeBZ1_z3T7gJHTrbsZ1t-jL0ScC5AtO-_QN9C03dd-xbkOwBpRaOesI0wSjYKLDxlm7_IKXtO9AMAetXaZ-xU6Nb0ypgN-351v61IlErmZeRhH6ZS7vd3mD1hI3nKfEwZm4wYJ-Setqn6BYmPtcx8qOhp4cHXkHKZPfc58gFzust_ejHRGpFesJPRT4Qvj_GMfft49fXyc3Nz--n68uKmCRrs0litIYLQ6EPog-0Hv9a7EMbQi8G0Qttoldej8aoN0WgLUuMwrDmA6Uapztibw95tLT93SIubEwWcJp-x7Mh1QstWaruC5gCGWogqjm5b0-zr3glwD4rdo2L34M-BdI-KnVrnXh8P7IYZ47-po9MV-HAAcH3zV8LqKCTMAWOqGBYXS_rPid9iaozy</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Sučić, M</creator><creator>Boban, D</creator><creator>Marković-Glamočak, M</creator><creator>Jakić-Razumović, J</creator><creator>Vrbanec, D</creator><creator>Ries, S</creator><creator>Gjadrov-Kuveždić, K</creator><creator>Čobanov, A.M</creator><creator>Podolski, P</creator><creator>Martinović, I</creator><creator>Erak, V</creator><creator>Budišić, Z</creator><creator>Ivrlač, R</creator><creator>Unušić, J</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases</title><author>Sučić, M ; Boban, D ; Marković-Glamočak, M ; Jakić-Razumović, J ; Vrbanec, D ; Ries, S ; Gjadrov-Kuveždić, K ; Čobanov, A.M ; Podolski, P ; Martinović, I ; Erak, V ; Budišić, Z ; Ivrlač, R ; Unušić, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-8440d014eacc9c89bac407ccfc91b56148d83a4f5a36cd548024ebb6cd0057f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biopsy, Fine-Needle</topic><topic>breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cyclooxygenase 2</topic><topic>cytooxygenase</topic><topic>Female</topic><topic>Fibroadenoma - metabolism</topic><topic>Fibroadenoma - pathology</topic><topic>Fibrocystic Breast Disease - metabolism</topic><topic>Fibrocystic Breast Disease - pathology</topic><topic>Humans</topic><topic>Isoenzymes - biosynthesis</topic><topic>Membrane Proteins</topic><topic>Middle Aged</topic><topic>Prostaglandin-Endoperoxide Synthases - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sučić, M</creatorcontrib><creatorcontrib>Boban, D</creatorcontrib><creatorcontrib>Marković-Glamočak, M</creatorcontrib><creatorcontrib>Jakić-Razumović, J</creatorcontrib><creatorcontrib>Vrbanec, D</creatorcontrib><creatorcontrib>Ries, S</creatorcontrib><creatorcontrib>Gjadrov-Kuveždić, K</creatorcontrib><creatorcontrib>Čobanov, A.M</creatorcontrib><creatorcontrib>Podolski, P</creatorcontrib><creatorcontrib>Martinović, I</creatorcontrib><creatorcontrib>Erak, V</creatorcontrib><creatorcontrib>Budišić, Z</creatorcontrib><creatorcontrib>Ivrlač, R</creatorcontrib><creatorcontrib>Unušić, J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sučić, M</au><au>Boban, D</au><au>Marković-Glamočak, M</au><au>Jakić-Razumović, J</au><au>Vrbanec, D</au><au>Ries, S</au><au>Gjadrov-Kuveždić, K</au><au>Čobanov, A.M</au><au>Podolski, P</au><au>Martinović, I</au><au>Erak, V</au><au>Budišić, Z</au><au>Ivrlač, R</au><au>Unušić, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases</atitle><jtitle>Breast (Edinburgh)</jtitle><addtitle>Breast</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>12</volume><issue>1</issue><spage>51</spage><epage>57</epage><pages>51-57</pages><issn>0960-9776</issn><eissn>1532-3080</eissn><abstract>Numerous studies have demonstrated that the levels of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H
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| subjects | Adult Biopsy, Fine-Needle breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cyclooxygenase 2 cytooxygenase Female Fibroadenoma - metabolism Fibroadenoma - pathology Fibrocystic Breast Disease - metabolism Fibrocystic Breast Disease - pathology Humans Isoenzymes - biosynthesis Membrane Proteins Middle Aged Prostaglandin-Endoperoxide Synthases - biosynthesis |
| title | Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases |
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