Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to result from uncontrolled inflammatory responses to microbial infection and/or components. However, failure of several experimental anti-inflammatory therapies has necessitated re-evaluation of the paradigm unde...

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Veröffentlicht in:	FEBS letters 2003-12, Vol.555 (2), p.180-184
Hauptverfasser:	Joshi, Vishwas D, Kalvakolanu, Dhananjaya V, Cross, Alan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Caspase 1 - metabolism Complement C5a - metabolism Cytokines - metabolism Disease Models, Animal Humans Inflammation Inflammation - metabolism Lipopolysaccharides - immunology Lipopolysaccharides - metabolism Lymphocytes - cytology Lymphocytes - immunology Mitogen-Activated Protein Kinases - metabolism Sepsis Shock, Septic - drug therapy Shock, Septic - immunology Shock, Septic - metabolism Shock, Septic - pathology Tumor Necrosis Factor-alpha - metabolism
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