Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection
SUMMARY Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self‐controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute afte...
Gespeichert in:
| Veröffentlicht in: | Diseases of the esophagus 2003-01, Vol.16 (4), p.291-294 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 294 |
|---|---|
| container_issue | 4 |
| container_start_page | 291 |
| container_title | Diseases of the esophagus |
| container_volume | 16 |
| creator | Kalmár, K. Vereczkei Zámbó, K. Pótó, L. Horváth, Ö. P. |
| description | SUMMARY Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self‐controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. Between 1995 and 1998 15 patients with gastric pull up, 10 patients with colon replacement or bypass and eight patients with free jejunum transplant or jejunum replacement were evaluated. Esophageal transit scintigraphy was performed before and after cisapride administration. From the time–activity curves, the half‐life of radiolabeled bolus in the esophagus was calculated and preadministration and postadministration half‐lives were compared. Cisapride significantly reduced the half‐life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection. |
| doi_str_mv | 10.1111/j.1442-2050.2003.00349.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71425104</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71425104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4539-4750502822c58b9d32c528da66560ff74b5126467957b838e343b4817232234c3</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhiMEoqXwF5BPnEjwZ-wcOKBtaZFWdA9FPVqOM9n11omDnVW3Z_44XnYpVyxZM9Y874z8TlEggiuSz6dtRTinJcUCVxRjVuXLm2r_ojh_LrzMOaG4VHXDz4o3KW0xJpLV6nVxRnjNCW3IefFrFcODG2F2FkHfg51R6JF1yUzRdYDCiCbonPXQoTSHwdjNR5QG4z1qwyN4ZMYO2eAzt46mnxOKMHlj3bhG8wYQpDBtzHqXUC5C_PsG4zOY8jgXxrfFq974BO9O8aL48fXqbnFTLm-vvy2-LEvLBWtKLkX-FlWUWqHapmM5UtWZuhY17nvJW0FozWvZCNkqpoBx1nJFJGWUMm7ZRfHh2HeK4ecO0qwHlyx4b0YIu6Ql4VQQzDOojqCNIaUIvc5mDCY-aYL1YQF6qw8-64PP-rAA_WcBep-l708zdu0A3T_hyfEMfD4Cj87D03831pe3d1c5y_ryqHdphv2z3sQHXUsmhb7_fq2XNyu1Eguu79lvUSSjbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71425104</pqid></control><display><type>article</type><title>Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>Oxford Journals</source><creator>Kalmár, K. ; Vereczkei ; Zámbó, K. ; Pótó, L. ; Horváth, Ö. P.</creator><creatorcontrib>Kalmár, K. ; Vereczkei ; Zámbó, K. ; Pótó, L. ; Horváth, Ö. P.</creatorcontrib><description>SUMMARY Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self‐controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. Between 1995 and 1998 15 patients with gastric pull up, 10 patients with colon replacement or bypass and eight patients with free jejunum transplant or jejunum replacement were evaluated. Esophageal transit scintigraphy was performed before and after cisapride administration. From the time–activity curves, the half‐life of radiolabeled bolus in the esophagus was calculated and preadministration and postadministration half‐lives were compared. Cisapride significantly reduced the half‐life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection.</description><identifier>ISSN: 1120-8694</identifier><identifier>EISSN: 1442-2050</identifier><identifier>DOI: 10.1111/j.1442-2050.2003.00349.x</identifier><identifier>PMID: 14641291</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Cisapride - pharmacology ; cisaprode ; Colon - transplantation ; deglutition ; Deglutition - drug effects ; Esophagectomy ; Esophagus - diagnostic imaging ; Esophagus - physiology ; Esophagus - surgery ; Female ; Gastrointestinal Agents - pharmacology ; half life ; Humans ; Intestine, Small - transplantation ; Male ; Middle Aged ; Postoperative Period ; Radionuclide Imaging ; Stomach - transplantation ; Transplants</subject><ispartof>Diseases of the esophagus, 2003-01, Vol.16 (4), p.291-294</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4539-4750502822c58b9d32c528da66560ff74b5126467957b838e343b4817232234c3</citedby><cites>FETCH-LOGICAL-c4539-4750502822c58b9d32c528da66560ff74b5126467957b838e343b4817232234c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-2050.2003.00349.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-2050.2003.00349.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14641291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalmár, K.</creatorcontrib><creatorcontrib>Vereczkei</creatorcontrib><creatorcontrib>Zámbó, K.</creatorcontrib><creatorcontrib>Pótó, L.</creatorcontrib><creatorcontrib>Horváth, Ö. P.</creatorcontrib><title>Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection</title><title>Diseases of the esophagus</title><addtitle>Dis Esophagus</addtitle><description>SUMMARY Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self‐controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. Between 1995 and 1998 15 patients with gastric pull up, 10 patients with colon replacement or bypass and eight patients with free jejunum transplant or jejunum replacement were evaluated. Esophageal transit scintigraphy was performed before and after cisapride administration. From the time–activity curves, the half‐life of radiolabeled bolus in the esophagus was calculated and preadministration and postadministration half‐lives were compared. Cisapride significantly reduced the half‐life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection.</description><subject>Adult</subject><subject>Cisapride - pharmacology</subject><subject>cisaprode</subject><subject>Colon - transplantation</subject><subject>deglutition</subject><subject>Deglutition - drug effects</subject><subject>Esophagectomy</subject><subject>Esophagus - diagnostic imaging</subject><subject>Esophagus - physiology</subject><subject>Esophagus - surgery</subject><subject>Female</subject><subject>Gastrointestinal Agents - pharmacology</subject><subject>half life</subject><subject>Humans</subject><subject>Intestine, Small - transplantation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Period</subject><subject>Radionuclide Imaging</subject><subject>Stomach - transplantation</subject><subject>Transplants</subject><issn>1120-8694</issn><issn>1442-2050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoqXwF5BPnEjwZ-wcOKBtaZFWdA9FPVqOM9n11omDnVW3Z_44XnYpVyxZM9Y874z8TlEggiuSz6dtRTinJcUCVxRjVuXLm2r_ojh_LrzMOaG4VHXDz4o3KW0xJpLV6nVxRnjNCW3IefFrFcODG2F2FkHfg51R6JF1yUzRdYDCiCbonPXQoTSHwdjNR5QG4z1qwyN4ZMYO2eAzt46mnxOKMHlj3bhG8wYQpDBtzHqXUC5C_PsG4zOY8jgXxrfFq974BO9O8aL48fXqbnFTLm-vvy2-LEvLBWtKLkX-FlWUWqHapmM5UtWZuhY17nvJW0FozWvZCNkqpoBx1nJFJGWUMm7ZRfHh2HeK4ecO0qwHlyx4b0YIu6Ql4VQQzDOojqCNIaUIvc5mDCY-aYL1YQF6qw8-64PP-rAA_WcBep-l708zdu0A3T_hyfEMfD4Cj87D03831pe3d1c5y_ryqHdphv2z3sQHXUsmhb7_fq2XNyu1Eguu79lvUSSjbQ</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Kalmár, K.</creator><creator>Vereczkei</creator><creator>Zámbó, K.</creator><creator>Pótó, L.</creator><creator>Horváth, Ö. P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection</title><author>Kalmár, K. ; Vereczkei ; Zámbó, K. ; Pótó, L. ; Horváth, Ö. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4539-4750502822c58b9d32c528da66560ff74b5126467957b838e343b4817232234c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Cisapride - pharmacology</topic><topic>cisaprode</topic><topic>Colon - transplantation</topic><topic>deglutition</topic><topic>Deglutition - drug effects</topic><topic>Esophagectomy</topic><topic>Esophagus - diagnostic imaging</topic><topic>Esophagus - physiology</topic><topic>Esophagus - surgery</topic><topic>Female</topic><topic>Gastrointestinal Agents - pharmacology</topic><topic>half life</topic><topic>Humans</topic><topic>Intestine, Small - transplantation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Period</topic><topic>Radionuclide Imaging</topic><topic>Stomach - transplantation</topic><topic>Transplants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalmár, K.</creatorcontrib><creatorcontrib>Vereczkei</creatorcontrib><creatorcontrib>Zámbó, K.</creatorcontrib><creatorcontrib>Pótó, L.</creatorcontrib><creatorcontrib>Horváth, Ö. P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of the esophagus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalmár, K.</au><au>Vereczkei</au><au>Zámbó, K.</au><au>Pótó, L.</au><au>Horváth, Ö. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection</atitle><jtitle>Diseases of the esophagus</jtitle><addtitle>Dis Esophagus</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>16</volume><issue>4</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>1120-8694</issn><eissn>1442-2050</eissn><abstract>SUMMARY Cisapride is a potent third generation prokinetic agent acting on postganglionic receptors by increasing the release of acetylcholine. In a prospective, self‐controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used for substitute after esophageal resection. Between 1995 and 1998 15 patients with gastric pull up, 10 patients with colon replacement or bypass and eight patients with free jejunum transplant or jejunum replacement were evaluated. Esophageal transit scintigraphy was performed before and after cisapride administration. From the time–activity curves, the half‐life of radiolabeled bolus in the esophagus was calculated and preadministration and postadministration half‐lives were compared. Cisapride significantly reduced the half‐life of radiolabeled bolus in the substitute in the case of stomach and jejunum replacement, while for colon replacement the results were dispersed too widely to yield significant difference. Cisapride exerts prokinetic effect on pedicled stomach and jejunum substitutes after esophageal resection.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14641291</pmid><doi>10.1111/j.1442-2050.2003.00349.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1120-8694 |
| ispartof | Diseases of the esophagus, 2003-01, Vol.16 (4), p.291-294 |
| issn | 1120-8694 1442-2050 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71425104 |
| source | MEDLINE; Wiley Online Library All Journals; Oxford Journals |
| subjects | Adult Cisapride - pharmacology cisaprode Colon - transplantation deglutition Deglutition - drug effects Esophagectomy Esophagus - diagnostic imaging Esophagus - physiology Esophagus - surgery Female Gastrointestinal Agents - pharmacology half life Humans Intestine, Small - transplantation Male Middle Aged Postoperative Period Radionuclide Imaging Stomach - transplantation Transplants |
| title | Prokinetic effect of cisapride on pedicled stomach, small bowel and colon grafts replacing the esophagus after esophageal resection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T09%3A44%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prokinetic%20effect%20of%20cisapride%20on%20pedicled%20stomach,%20small%20bowel%20and%20colon%20grafts%20replacing%20the%20esophagus%20after%20esophageal%20resection&rft.jtitle=Diseases%20of%20the%20esophagus&rft.au=Kalm%C3%A1r,%20K.&rft.date=2003-01-01&rft.volume=16&rft.issue=4&rft.spage=291&rft.epage=294&rft.pages=291-294&rft.issn=1120-8694&rft.eissn=1442-2050&rft_id=info:doi/10.1111/j.1442-2050.2003.00349.x&rft_dat=%3Cproquest_cross%3E71425104%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71425104&rft_id=info:pmid/14641291&rfr_iscdi=true |