Reduced laterality of the source locations for generators of the auditory steady-state field in schizophrenia
Reduced hemispheric asymmetry of evoked field generators in schizophrenia in secondary auditory cortex has been replicated with mixed success. This disparity is possibly due to the complex nature of the 100-msec generators typically investigated. In this study, we evaluated a source located in prima...
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| Veröffentlicht in: | Biological psychiatry (1969) 2003-12, Vol.54 (11), p.1149-1153 |
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| container_title | Biological psychiatry (1969) |
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| creator | Teale, Peter Carlson, Jon Rojas, Donald Reite, Martin |
| description | Reduced hemispheric asymmetry of evoked field generators in schizophrenia in secondary auditory cortex has been replicated with mixed success. This disparity is possibly due to the complex nature of the 100-msec generators typically investigated. In this study, we evaluated a source located in primary auditory cortex, responsible for the steady-state response, to determine whether similar asymmetries were present.
Contralateral evoked fields were recorded with a 37-channel neuromagnetometer in response to 40-Hz pulse trains. Dipole models were used to localize the sources in both hemispheres of schizophrenic subjects (
n = 17) and normal control subjects (
n = 18).
Control subjects were asymmetrically lateralized, with sources in the right hemisphere approximately 6 mm further anterior than those on the left. In contrast, schizophrenic subjects showed no significant difference between hemispheres.
The findings support theories linking schizophrenia to disturbed asymmetry of temporal lobe function. The steady-state response, having a more discrete Heschl’s gyrus generator location, may be better suited for evaluating auditory asymmetry. |
| doi_str_mv | 10.1016/S0006-3223(03)00411-6 |
| format | Article |
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Contralateral evoked fields were recorded with a 37-channel neuromagnetometer in response to 40-Hz pulse trains. Dipole models were used to localize the sources in both hemispheres of schizophrenic subjects (
n = 17) and normal control subjects (
n = 18).
Control subjects were asymmetrically lateralized, with sources in the right hemisphere approximately 6 mm further anterior than those on the left. In contrast, schizophrenic subjects showed no significant difference between hemispheres.
The findings support theories linking schizophrenia to disturbed asymmetry of temporal lobe function. The steady-state response, having a more discrete Heschl’s gyrus generator location, may be better suited for evaluating auditory asymmetry.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(03)00411-6</identifier><identifier>PMID: 14643081</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; auditory ; Auditory Perception - physiology ; Biological and medical sciences ; Brain - physiopathology ; Female ; Functional Laterality - physiology ; hemispheric asymmetry ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetoencephalography ; Male ; Medical sciences ; Nervous system ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; primary auditory cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; steady-state response</subject><ispartof>Biological psychiatry (1969), 2003-12, Vol.54 (11), p.1149-1153</ispartof><rights>2003 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-fb11600b5b8c1a641b2b90599203ba1a92df58ebf9f898abbcad64c8309519ed3</citedby><cites>FETCH-LOGICAL-c509t-fb11600b5b8c1a641b2b90599203ba1a92df58ebf9f898abbcad64c8309519ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(03)00411-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15334616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14643081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teale, Peter</creatorcontrib><creatorcontrib>Carlson, Jon</creatorcontrib><creatorcontrib>Rojas, Donald</creatorcontrib><creatorcontrib>Reite, Martin</creatorcontrib><title>Reduced laterality of the source locations for generators of the auditory steady-state field in schizophrenia</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Reduced hemispheric asymmetry of evoked field generators in schizophrenia in secondary auditory cortex has been replicated with mixed success. This disparity is possibly due to the complex nature of the 100-msec generators typically investigated. In this study, we evaluated a source located in primary auditory cortex, responsible for the steady-state response, to determine whether similar asymmetries were present.
Contralateral evoked fields were recorded with a 37-channel neuromagnetometer in response to 40-Hz pulse trains. Dipole models were used to localize the sources in both hemispheres of schizophrenic subjects (
n = 17) and normal control subjects (
n = 18).
Control subjects were asymmetrically lateralized, with sources in the right hemisphere approximately 6 mm further anterior than those on the left. In contrast, schizophrenic subjects showed no significant difference between hemispheres.
The findings support theories linking schizophrenia to disturbed asymmetry of temporal lobe function. The steady-state response, having a more discrete Heschl’s gyrus generator location, may be better suited for evaluating auditory asymmetry.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>auditory</subject><subject>Auditory Perception - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>hemispheric asymmetry</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetoencephalography</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>primary auditory cortex</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>steady-state response</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVuLFDEQRoO4uOPqT1DyouhDaypJZ7qfFlm8LCwIXp5DLhUn0tMZk_TC-OvNOKP7uFAQCk59VZwQ8gzYG2Cg3n5ljKlOcC5eMfGaMQnQqQdkBcNadFwy_pCs_iPn5HEpP1u75hwekXOQSgo2wIpsv6BfHHo6mYrZTLHuaQq0bpCWtGSHdErO1JjmQkPK9AfODaspl3-YWXxs_Z6Wisbvu1JbEg0RJ0_jTIvbxN9pt8k4R_OEnAUzFXx6ei_I9w_vv1196m4-f7y-enfTuZ6NtQsWQDFmezs4MEqC5XZk_ThyJqwBM3If-gFtGMMwDsZaZ7ySbhBs7GFELy7Iy2PuLqdfC5aqt7E4nCYzY1qKXoPkkivRwP4IupxKyRj0LsetyXsNTB8867-e9UGiZq0OnrVqc89PCxa7RX83dRLbgBcnwBRnppDN7GK543ohpIJD0OWRw6bjNmLWxUWc24_EjK5qn-I9p_wBEkKbbg</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Teale, Peter</creator><creator>Carlson, Jon</creator><creator>Rojas, Donald</creator><creator>Reite, Martin</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Reduced laterality of the source locations for generators of the auditory steady-state field in schizophrenia</title><author>Teale, Peter ; Carlson, Jon ; Rojas, Donald ; Reite, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-fb11600b5b8c1a641b2b90599203ba1a92df58ebf9f898abbcad64c8309519ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>auditory</topic><topic>Auditory Perception - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>hemispheric asymmetry</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetoencephalography</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>primary auditory cortex</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>steady-state response</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teale, Peter</creatorcontrib><creatorcontrib>Carlson, Jon</creatorcontrib><creatorcontrib>Rojas, Donald</creatorcontrib><creatorcontrib>Reite, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teale, Peter</au><au>Carlson, Jon</au><au>Rojas, Donald</au><au>Reite, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced laterality of the source locations for generators of the auditory steady-state field in schizophrenia</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>54</volume><issue>11</issue><spage>1149</spage><epage>1153</epage><pages>1149-1153</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Reduced hemispheric asymmetry of evoked field generators in schizophrenia in secondary auditory cortex has been replicated with mixed success. This disparity is possibly due to the complex nature of the 100-msec generators typically investigated. In this study, we evaluated a source located in primary auditory cortex, responsible for the steady-state response, to determine whether similar asymmetries were present.
Contralateral evoked fields were recorded with a 37-channel neuromagnetometer in response to 40-Hz pulse trains. Dipole models were used to localize the sources in both hemispheres of schizophrenic subjects (
n = 17) and normal control subjects (
n = 18).
Control subjects were asymmetrically lateralized, with sources in the right hemisphere approximately 6 mm further anterior than those on the left. In contrast, schizophrenic subjects showed no significant difference between hemispheres.
The findings support theories linking schizophrenia to disturbed asymmetry of temporal lobe function. The steady-state response, having a more discrete Heschl’s gyrus generator location, may be better suited for evaluating auditory asymmetry.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14643081</pmid><doi>10.1016/S0006-3223(03)00411-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 2003-12, Vol.54 (11), p.1149-1153 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Adult and adolescent clinical studies auditory Auditory Perception - physiology Biological and medical sciences Brain - physiopathology Female Functional Laterality - physiology hemispheric asymmetry Humans Investigative techniques, diagnostic techniques (general aspects) Magnetoencephalography Male Medical sciences Nervous system Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques primary auditory cortex Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnosis Schizophrenia - physiopathology Schizophrenic Psychology steady-state response |
| title | Reduced laterality of the source locations for generators of the auditory steady-state field in schizophrenia |
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