Controlled release of estradiol solubilized in carbopol/surfactant aggregates

The potential of carbopol/surfactant dispersions as solubilizing and controlled release systems of estradiol (a poorly water-soluble drug) was evaluated. The solubilization of estradiol in the dispersions of Carbopol® 934 (0.25%) and Pluronic F-127, Tween 80, sodium dodecylsulfate (SDS), or benzalko...

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Veröffentlicht in:	Journal of controlled release 2003-12, Vol.93 (3), p.319-330
Hauptverfasser:	Barreiro-Iglesias, Rafael, Alvarez-Lorenzo, Carmen, Concheiro, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins Biological and medical sciences Carbopol 934 Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Estradiol - chemistry Estradiol - pharmacokinetics General pharmacology Hormones. Endocrine system Hydrophobic drug solubilization Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymer/surfactant aggregation Polyvinyls - chemistry Polyvinyls - pharmacokinetics Sodium dodecylsulfate Solubility - drug effects Surface-Active Agents - chemistry Surface-Active Agents - pharmacokinetics Tween 80
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